Published in:
Open Access
01-05-2014 | ePoster presentation
Design, synthesis and biological evaluation on N- heteroaryl compounds as probable NNRTIs against laboratory adapted strains and the primary isolates of HIV-1
Authors:
Anuradha Singh, Madhu Yadav, Ritika Srivastava, Nidhi Singh, Ashwini Godse, Rahul Suryawanshi, Ashwini Dhamanage, Smita Kulkarni, Ramendra K Singh
Published in:
BMC Infectious Diseases
|
Special Issue 3/2014
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Excerpt
The emergence of drug resistant HIV strains and suitability of NNRTIs as potent anti-HIV molecules used in HAART did attract our attention towards developing NNRTIs. We, therefore, focused on developing some new NNRTIs utilizing benzimidazole and pyrimidine moieties to match the hydrophobic nature of the allosteric pocket in HIV-RT. …