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Open Access 01-12-2015 | Poster presentation

Design, method and application of stopping rules in a phase III 2x2 factorial randomised controlled trial

Authors: Megan Bowers, Louise Stanton, Mark Thursz

Published in: Trials | Special Issue 2/2015

Excerpt

The STOPAH trial was a double-blind, 2x2 factorial, phase III randomised clinical trial assessing the treatment of prednisolone and pentoxifylline in patients with severe alcoholic hepatitis; a study that aimed to evaluate 28-day mortality [1]. …

Forrest , et al: Steroids or pentoxifylline for alcoholic hepatitis (STOPAH): study protocol for a randomised controlled trial. Trials. 2013, 14: 262-CrossRefPubMedPubMedCentral

Pocock SJ: Current controversies in data monitoring for clinical trials. Clin Trials. 2006, 3: 513-CrossRefPubMed

Thursz , et al: Prednisolone or Pentoxifylline for Alcoholic Hepatitis. N Engl J Med. 2015, 372: 1619-1628.CrossRefPubMed

Title: Design, method and application of stopping rules in a phase III 2x2 factorial randomised controlled trial
Authors: Megan Bowers
Louise Stanton
Mark Thursz
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Trials / Issue Special Issue 2/2015
Electronic ISSN: 1745-6215
DOI: https://doi.org/10.1186/1745-6215-16-S2-P207

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Design, method and application of stopping rules in a phase III 2x2 factorial randomised controlled trial

Excerpt

Keynote webinar | Spotlight on medication adherence

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