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Trials
Published in: Trials 2/2015

Open Access 01-12-2015 | Poster presentation

Addressing the barriers to implementing model based designs in dose escalation studies

Authors: Victoria Cornelius, Simon Bond

Published in: Trials | Special Issue 2/2015

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Excerpt

Dose escalation studies are undertaken to determine the recommended dose for later phase trials, often the maximum tolerated dose that can be administered beyond which the rate of toxicity events becomes too high. The advantages of model-based designs over rule based approaches (such as the 3+3 design) have been established for many years. While further innovations in design are being developed by the statistical community, a large number of trial investigators remain using the 3+3 design. …
Metadata
Title
Addressing the barriers to implementing model based designs in dose escalation studies
Authors
Victoria Cornelius
Simon Bond
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Trials / Issue Special Issue 2/2015
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-16-S2-P235

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