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Rheumatology International
Published in: Rheumatology International 9/2009

01-06-2009 | Case Report

Dermatomyositis, complicated with pneumomediastinum, successfully treated with cyclosporine A: a case report and review of literature

Authors: Hui-Jung Kim, Yun-Kyung Hong, Wan-Hee Yoo

Published in: Rheumatology International | Issue 9/2009

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Abstract

We report a rare case of patient with dermatomyositis (DM) who developed spontaneous pneumomediastinum (PnM) and subcutaneous emphysema. She was successfully treated with oral prednisolone and cyclosporine A (CsA). We reviewed the cases of PnM in patients with DM treated with CsA. A review of four previously reported cases revealed that treatment with systemic glucocorticoid and CsA was effective for the DM and PnM. We indicate that initial and early treatment of the patients with DM and PnM with CsA enabled rapid tapering of the dose of glucocorticoid and improved the disease.
Literature
1.
Dickey BF, Myers AR (1984) Pulmonary disease in polymyositis and dermatomyositis. Semin Arthritis Rheum 41:137–140
2.
King TE, Cherniack RM, Schwarz MI (1994) The lungs and connective tissue disease. In: Murray JF, Nadel JA (eds) Textbook of respiratory medicine. Saunders, Philadelphia, pp 1850–1872
3.
Yarborough JW, Sealy WC, Millar JA (1975) Thoracic surgical problems associated with rheumatoid arthritis. J Thorac Cardiovasc Surg 69:347–354
4.
5.
6.
7.
Neves FS, Shinjo SK, Carvalho JF, Levy-Neto M, Borges CT (2007) Spontaneous pneumomediastinum and dermatomyositis may be a not so rare association: report of a case and review of the literature. Clin Rheumatol 26:105–107. doi:10.​1007/​s10067-005-0109-x CrossRef
8.
9.
Yamanashi Y, Maeda H, Konishi F, Hiyama K, Yamana S, Ishioka S et al (1999) Dermatomyositis associated with rapidly progressive fatal interstitial pneumonitis and pneumomediastinum. Scand J Rheumatol 28:58–61. doi:10.​1080/​0300974995015580​5 CrossRef
10.
Jansen TL, Barrera P, van Engelen BG, Cox N, Laan RF, van de Putte LB (1998) Dermatonyositis with subclinical myositis and spontaneous pneumomediastinum with pneumothorax: case report and review of the literature. Clin Exp Rheumatol 16:733–735PubMed
11.
Englund P, Lindroos E, Nennesmo I, Klareskog L, Lundberg IE (2001) Skeletal muscle fibers express major histocompatibility complex class II antigens independently of inflammatory infiltrates in inflammatory myopathies. Am J Pathol 159:1263–1273PubMed
12.
Inukai A, Kuru S, Liang Y, Takano A, Kobayashi Y, Sakai M et al (2000) Expression of HLA-DR and its enhancing molecules in muscle fibers in polymyositis. Muscle Nerve 23:385–392. doi:10.1002/(SICI)1097-4598(200003)23:3<385::AID-MUS10>3.0.CO;2-TPubMedCrossRef
13.
14.
Engel AG, Arahata K, Emslie-Smith A (1990) Immune effector mechanisms in inflammatory myopathies. Res Publ Assoc Res Nerv Ment Dis 68:141–157PubMed
15.
Arahata K, Engel AG (1984) Monoclonal antibody analysis of mononuclear cells in myopathies I: quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells. Ann Neurol 16:193–208. doi:10.​1002/​ana.​410160206 PubMedCrossRef
16.
Yamadori I, Fujita J, Kajitani H, Bandoh S, Tokuda M, Ohtsuki Y et al (2001) Lymphocyte subsets in lung tissues of interstitial pneumonia associated with untreated polymyositis/dermatomyositis. Rheumatol Int 21:89–93. doi:10.​1007/​s00296-001-0146-y PubMedCrossRef
17.
Chino Y, Murata H, Goto D, Matsumoto I, Tsutsumi A, Sakamoto T et al (2006) T cell receptor BV gene repertoire of lymphocytes in bronchoalveolar lavage fluid of polymyositis/dermatomyositis patients with interstitial pneumonitis. Int J Mol Med 17:101–109PubMed
18.
Giese T, Zeier M, Schemmer P, Uhl W, Schoels M, Dengler T et al (2004) Monitoring of NFAT-regulated gene expression in the peripheral blood of allograft recipients: a novel perspective toward individually optimized drug doses of cyclosporine A. Transplantation 77:339–344. doi:10.​1097/​01.​TP.​0000109260.​00094.​01 PubMedCrossRef
19.
Saggi SJ, Andoh TF, Safirstein R, Bennett WM (2004) Cyclosporin induces renal proto-oncogene RNA message and increased transforming growth factor beta prior to renal fibrosis: modification by calcium channel blockade in the salt-repleted rat. Nephrology 9:58–64. doi:10.​1111/​j.​1440-1797.​2003.​00230.​x PubMedCrossRef
20.
21.
Qushmaq KA, Chalmers A, Esdaile JM (2000) Cyclosporine A in the treatment of refractory adult polymyositis/dermatomyositis population-based experience in 6 patients and literature review. J Rheumatol 27:2855–2859PubMed
22.
23.
24.
Nonomura Y, Koike R, Nishio J, Tsubata R, Kohsaka H, Kubota T, Miyasaka N (2001) A case of dermatomyositis complicated with pneumomediastinum that was successfully treated with cyclosporin A. Ryumachi 41:653–658PubMed
Metadata
Title
Dermatomyositis, complicated with pneumomediastinum, successfully treated with cyclosporine A: a case report and review of literature
Authors
Hui-Jung Kim
Yun-Kyung Hong
Wan-Hee Yoo
Publication date
01-06-2009
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 9/2009
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-008-0822-2

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Keynote webinar | Spotlight on medication adherence

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