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Current Diabetes Reports
Published in: Current Diabetes Reports 1/2014

01-01-2014 | Pediatric Type 2 Diabetes (PS Zeitler, Section Editor)

Depression and Quality of Life in Youth-Onset Type 2 Diabetes Mellitus

Author: Natalie Walders-Abramson

Published in: Current Diabetes Reports | Issue 1/2014

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Abstract

Type 2 Diabetes Mellitus (T2DM) was characteristically an adult-onset illness until recently, when it became recognized as an increasing problem among youth in conjunction with escalating rates and associated risks of pediatric. Youth-onset T2DM is associated with a range of psychosocial risk factors, and research underscores the relevancy of depressive symptoms and quality of life factors in illness diagnosis, management and prognosis. This review paper summarizes available findings on depression and health-related quality of life for youth-onset T2DM, and provides recommendations for clinical practice and a conceptual framework for further studies.
Literature
1.
Pinhas-Hamiel O, Dolan LM, Daniels SR, Standiford D, Khoury PR, Zeitler P. Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J Pediatr. 1996;128:608–15.PubMedCrossRef
2.
Peterson K, Silverstein J, Kaufman F, Warren-Boulton E. Management of type 2 diabetes in youth: an update. Am Fam Physician. 2007;76:658–64.PubMed
3.
•• Springer SC, Silverstein J, Copeland K, et al. Management of type 2 diabetes mellitus in children and adolescents. Pediatrics. 2013;131:e648–64. This publication is a technical report from the American Academy of Pediatrics. featuring a systematic review of literature utilized to generate clinical practice guidelines for, “Management of Type 2 Diabetes Melllitus in Children and Adolescents”.PubMedCrossRef
4.
Zeitler P. Considerations regarding the diagnosis and treatment of childhood type 2 diabetes. Postgrad Med. 2010;122:89–97.PubMedCrossRef
5.
Rapid rise in hypertension and nephropathy in youth with type 2 diabetes: the TODAY clinical trial. Diabetes Care. 2013;36:1735–41.
6.
Lipid and inflammatory cardiovascular risk worsens over 3 years in youth with type 2 diabetes: the TODAY clinical trial. Diabetes Care. 2013;36:1758–64.
7.
Rhodes ET, Prosser LA, Hoerger TJ, Lieu T, Ludwig DS, Laffel LM. Estimated morbidity and mortality in adolescents and young adults diagnosed with Type 2 diabetes mellitus. Diabet Med. 2012;29:453–63.PubMedCrossRef
8.
Linder BL, Fradkin JE, Rodgers GP. The TODAY Study: an NIH perspective on its implications for research. Diabetes Care. 2013;36:1775–6.PubMedCrossRef
9.
10.
Fogel NR, Weissberg-Benchell J. Preventing poor psychological and health outcomes in pediatric type 1 diabetes. Curr Diab Rep. 2010;10:436–43.PubMedCrossRef
11.
•• Cefalu WT. “TODAY” reflects on the changing “Faces” of type 2 diabetes. Diabetes Care. 2013;36:1732–4. Commentary on findings related to treatment options for youth-onset type 2 diabetes and data examining rates and risks of complications associated with the condition.PubMedCrossRef
12.
Pinhas-Hamiel O, Zeitler P. Acute and chronic complications of type 2 diabetes mellitus in children and adolescents. Lancet. 2007;369:1823–31.PubMedCrossRef
13.
SEARCH for Diabetes in Youth: a multicenter study of the prevalence, incidence and classification of diabetes mellitus in youth. Control Clin Trials. 2004;25:458–71.
14.
Tamborlane WV, Klingensmith G. Crisis in care: limited treatment options for type 2 diabetes in adolescents and youth. Diabetes Care. 2013;36:1777–8.PubMedCrossRef
15.
•• Zeitler P, Hirst K, Pyle L, et al. A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med. 2012;366:2247–56. This manuscript summarizes the primary outcomes from the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study.PubMedCrossRef
16.
Louis-Jacques J, Samples C. Caring for teens with chronic illness: risky business? Curr Opin Pediatr. 2011;23:367–72.PubMedCrossRef
17.
Rolland JS, Walsh F. Facilitating family resilience with childhood illness and disability. Curr Opin Pediatr. 2006;18:527–38.PubMedCrossRef
18.
Rustad JK, Musselman DL, Nemeroff CB. The relationship of depression and diabetes: pathophysiological and treatment implications. Psychoneuroendocrinology. 2011;36:1276–86.PubMedCrossRef
19.
20.
Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24:1069–78.PubMedCrossRef
21.
Nouwen A, Winkley K, Twisk J, et al. Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia. 2010;53:2480–6.PubMedCentralPubMedCrossRef
22.
Talbot F, Nouwen A. A review of the relationship between depression and diabetes in adults: is there a link? Diabetes Care. 2000;23:1556–62.PubMedCrossRef
23.
Vallance JK, Winkler EA, Gardiner PA, Healy GN, Lynch BM, Owen N. Associations of objectively-assessed physical activity and sedentary time with depression: NHANES (2005-2006). Prev Med. 2011;53:284–8.PubMedCrossRef
24.
Knol MJ, Twisk JW, Beekman AT, Heine RJ, Snoek FJ, Pouwer F. Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia. 2006;49:837–45.PubMedCrossRef
25.
Jaser SS, Holl MG, Jefferson V, Grey M. Correlates of depressive symptoms in urban youth at risk for type 2 diabetes mellitus. J Sch Health. 2009;79:286–92.PubMedCrossRef
26.
de Groot M, Anderson R, Freedland KE, Clouse RE, Lustman PJ. Association of depression and diabetes complications: a meta-analysis. Psychosom Med. 2001;63:619–30.PubMed
27.
28.
• Baumeister H, Hutter N, Bengel J. Psychological and pharmacological interventions for depression in patients with diabetes mellitus and depression. Cochrane Database Syst Rev. 2012;12, CD008381. A review of the literature on behavioral health treatments for depression in patients with diabetes, summarizing glycemic and mental health outcomes.PubMed
29.
van Dooren FE, Nefs G, Schram MT, Verhey FR, Denollet J, Pouwer F. Depression and risk of mortality in people with diabetes mellitus: a systematic review and meta-analysis. PLoS One. 2013;8:e57058.PubMedCentralPubMedCrossRef
30.
Park M, Katon WJ, Wolf FM. Depression and risk of mortality in individuals with diabetes: a meta-analysis and systematic review. Gen Hosp Psychiatry. 2013;35:217–25.PubMedCrossRef
31.
Bakas T, McLennon SM, Carpenter JS, et al. Systematic review of health-related quality of life models. Health Qual Life Outcome. 2012;10:134.CrossRef
32.
Schunk M, Reitmeir P, Schipf S, et al. Health-related quality of life in subjects with and without Type 2 diabetes: pooled analysis of 5 population-based surveys in Germany. Diabet Med. 2012;29:646–53.PubMedCrossRef
33.
Green AJ, Fox KM, Grandy S. Self-reported hypoglycemia and impact on quality of life and depression among adults with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2012;96:313–8.PubMedCrossRef
34.
Landman GW, van Hateren KJ, Kleefstra N, Groenier KH, Gans RO, Bilo HJ. Health-related quality of life and mortality in a general and elderly population of patients with type 2 diabetes (ZODIAC-18). Diabetes Care. 2010;33:2378–82.PubMedCrossRef
35.
Li TC, Lee YD, Liu CS, Chen CC, Li CI, Lin CC. Disease-specific quality-of-life measures as predictors of mortality in individuals living with type 2 diabetes. J Psychosom Res. 2011;70:155–60.PubMedCrossRef
36.
Anderson RT, Narayan KM, Feeney P, et al. Effect of intensive glycemic lowering on health-related quality of life in type 2 diabetes: ACCORD trial. Diabetes Care. 2011;34:807–12.PubMedCrossRef
37.
Grandy S, Fox KM, Bazata DD. Association of self-reported weight change and quality of life, and exercise and weight management behaviors among adults with type 2 diabetes mellitus: the SHIELD study. Cardiol Res Pract. 2012;2012, 892564.PubMedCentralPubMed
38.
Williamson DA, Rejeski J, Lang W, Van Dorsten B, Fabricatore AN, Toledo K. Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. Arch Intern Med. 2009;169:163–71.PubMedCentralPubMedCrossRef
39.
Kalarchian MA, Marcus MD. Psychiatric comorbidity of childhood obesity. Int Rev Psychiatry. 2012;24:241–6.PubMedCrossRef
40.
Levitt Katz LE, Swami S, Abraham M, et al. Neuropsychiatric disorders at the presentation of type 2 diabetes mellitus in children. Pediatr Diabetes. 2005;6:84–9.PubMedCrossRef
41.
Block WM, Putzer GJ, Jaramillo JR. Children with type 2 diabetes mellitus and the prevalence of psychiatric disorders. South Med J. 2010;103:1214–8.PubMedCrossRef
42.
Anderson BJ, Edelstein S, Abramson NW, et al. Depressive symptoms and quality of life in adolescents with type 2 diabetes: baseline data from the TODAY study. Diabetes Care. 2011;34:2205–7.PubMedCrossRef
43.
Wilfley D, Berkowitz R, Goebel-Fabbri A, et al. Binge eating, mood, and quality of life in youth with type 2 diabetes: baseline data from the today study. Diabetes Care. 2011;34:858–60.PubMedCrossRef
44.
Hood KK, Lawrence JM, Anderson A, et al. Metabolic and inflammatory links to depression in youth with diabetes. Diabetes Care. 2012;35:2443–6.PubMedCrossRef
45.
Schwimmer JB, Burwinkle TM, Varni JW. Health-related quality of life of severely obese children and adolescents. JAMA. 2003;289:1813–9.PubMedCrossRef
46.
Nadeau K, Kolotkin RL, Boex R, et al. Health-related quality of life in adolescents with comorbidities related to obesity. J Adolesc Health. 2011;49:90–2.PubMedCrossRef
47.
Swallen KC, Reither EN, Haas SA, Meier AM. Overweight, obesity, and health-related quality of life among adolescents: the National Longitudinal Study of Adolescent Health. Pediatrics. 2005;115:340–7.PubMedCrossRef
48.
Varni JW, Limbers CA, Burwinkle TM, Bryant WP, Wilson DP. The ePedsQL in type 1 and type 2 diabetes: feasibility, reliability, and validity of the Pediatric Quality of Life Inventory Internet administration. Diabetes Care. 2008;31:672–7.PubMedCrossRef
49.
Allan CL, Flett B, Dean HJ. Quality of life in First Nation youth with type 2 diabetes. Matern Child Health J. 2008;12 Suppl 1:103–9.PubMedCrossRef
50.
Rhodes ET, Goran MI, Lieu TA, et al. Health-related quality of life in adolescents with or at risk for type 2 diabetes mellitus. J Pediatr. 2012;160:911–7.PubMedCrossRef
51.
Naughton MJ, Ruggiero AM, Lawrence JM, et al. Health-related quality of life of children and adolescents with type 1 or type 2 diabetes mellitus: SEARCH for Diabetes in Youth Study. Arch Pediatr Adolesc Med. 2008;162:649–57.PubMedCrossRef
52.
Anderson BJ, Cullen K, McKay S. Quality of life, family behavior, and health outcomes in children with type 2 diabetes. Pediatr Ann. 2005;34:722–9.PubMed
53.
Fisher L, Hessler DM, Polonsky WH, Mullan J. When is diabetes distress clinically meaningful?: establishing cut points for the Diabetes Distress Scale. Diabetes Care. 2012;35:259–64.PubMedCrossRef
54.
Delamater AM. Psychological care of children and adolescents with diabetes. Pediatr Diabetes. 2009;10 Suppl 12:175–84.PubMedCrossRef
55.
Bitsko MJ, Bean MK, Bart S, Foster RH, Thacker L, Francis GL. Psychological treatment improves hemoglobin a1c outcomes in adolescents with type 1 diabetes mellitus. J Clin Psychol Med Settings. 2013;20:333–42.
56.
Roy T, Lloyd CE, Pouwer F, Holt RI, Sartorius N. Screening tools used for measuring depression among people with Type 1 and Type 2 diabetes: a systematic review. Diabet Med. 2012;29:164–75.PubMedCrossRef
57.
Winkley K, Ismail K, Landau S, Eisler I. Psychological interventions to improve glycaemic control in patients with type 1 diabetes: systematic review and meta-analysis of randomised controlled trials. BMJ. 2006;333:65.PubMedCrossRef
58.
Pinhas-Hamiel O, Zeitler P. Clinical presentation and treatment of type 2 diabetes in children. Pediatr Diabetes. 2007;8 Suppl 9:16–27.PubMedCrossRef
59.
Barsky AJ. Amplification, somatization, and the somatoform disorders. Psychosomatics. 1992;33:28–34.PubMedCrossRef
Metadata
Title
Depression and Quality of Life in Youth-Onset Type 2 Diabetes Mellitus
Author
Natalie Walders-Abramson
Publication date
01-01-2014
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 1/2014
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-013-0449-x

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Diabetes and Pregnancy (CJ Homko, Section Editor)

Vitamin D and Gestational Diabetes Mellitus

Pediatric Type 2 Diabetes (PS Zeitler, Section Editor)

Changing Epidemiology of Metabolic Syndrome and Type 2 Diabetes in Chinese Youth

Diabetes and Pregnancy (CJ Homko, Section Editor)

The Role of Lifestyle Interventions in the Prevention of Gestational Diabetes

Pediatric Type 2 Diabetes (PS Zeitler, Section Editor)

Maternal and In Utero Determinants of Type 2 Diabetes Risk in the Young

Hospital Management of Diabetes (G Umpierrez, Section Editor)

Inpatient Hypoglycemia: A Challenge That Must Be Addressed

Hospital Management of Diabetes (G Umpierrez, Section Editor)

Diabetes and Hyperglycemia in the Critical Care Setting: Has the Evidence for Glycemic Control Vanished? (Or … Is Going Away?)
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