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The International Journal of Cardiovascular Imaging

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01-08-2012 | Original Paper

Demonstration of the Glagov phenomenon in vivo by CT coronary angiography in subjects with elevated Framingham risk

Authors: Sarah Rinehart, Zhen Qian, Gustavo Vazquez, Parag H. Joshi, Ben Kirkland, Kunal Bhatt, Idean Marvasty, Kim Christian, Szilard Voros

Published in: The International Journal of Cardiovascular Imaging | Issue 6/2012

Abstract

Computed tomography coronary angiography (CTA) is a novel, non-invasive method for coronary plaque detection and quantification. We hypothesized that CTA can detect early vessel wall thickening with preserved luminal size in patients without known coronary artery disease and intermediate/high Framingham Risk Score (FRS) compared to those with low FRS. Vessel-wall and plaque geometrical and compositional parameters were measured on CTA in 375 coronary segments with a highly standardized method. These parameters were then compared in patients with low versus intermediate/high FRS. The relationship between coronary artery calcium by non-contrast CT scanning (Agatston score) and percent atheroma volume (PAV) was determined by linear regression. P value <0.05 was considered significant. PAV and remodeling index were significantly higher in patients with intermediate/high FRS compared to those with low FRS (45.9 ± 6.8 vs. 42.3 ± 6.7; P = 0.004) and (0.97 ± 0.15 vs. 0.92 ± 0.13; P = 0.04), while minimal luminal diameter and minimal luminal area were similar. There was significant correlation between Agatston score and PAV (r ² = 0.42, P = 0.0036). However, Agatston score and plaque compositional parameters were similar between the groups. In conclusion, we demonstrated that CTA can detect early vessel-wall thickening with preserved luminal size in patients with intermediate/high versus low FRS.

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Title: Demonstration of the Glagov phenomenon in vivo by CT coronary angiography in subjects with elevated Framingham risk
Authors: Sarah Rinehart
Zhen Qian
Gustavo Vazquez
Parag H. Joshi
Ben Kirkland
Kunal Bhatt
Idean Marvasty
Kim Christian
Szilard Voros
Publication date: 01-08-2012
Publisher: Springer Netherlands
Published in: The International Journal of Cardiovascular Imaging / Issue 6/2012
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-011-9979-y

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Demonstration of the Glagov phenomenon in vivo by CT coronary angiography in subjects with elevated Framingham risk

Abstract

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