Top

Neurological Sciences

Published in:

18-08-2022 | Dementia | Review Article

N200 and P300 component changes in Parkinson’s disease: a meta-analysis

Authors: Hui Xu, Lihua Gu, Shiyao Zhang, Yuchen Wu, Xiaojin Wei, Caiyan Wang, Yuhan Xu, Yijing Guo

Published in: Neurological Sciences | Issue 12/2022

Abstract

Background

Cognitive impairment can seriously affect the quality of life of Parkinson’s disease (PD) patients. Although numerous studies showed that N200, P300 latency and amplitude are correlated with cognitive functions, there is a sufficient amount of controversial results. Therefore, it is necessary to conduct a meta-analysis of N200, P300 latency and amplitude data of event-related potential (ERP) in PD.

Methods

We systematically searched on PubMed and Web of Science for PD-related ERP studies published before December 2021. Standard mean difference (SMD) and 95% confidence interval (CI) estimates of N200 and P300 components were compared among PD patients, PD dementia (PDD) patients, PD non-dementia (PDND) patient, and healthy control (HC).

Results

Our meta-analysis showed prolonged N200 latency at the Fz, Cz electrode sites, prolonged P300 latency at the Fz sites in PD patients, compared to HC; prolonged N200 latency at the Cz, Pz electrode sites in PDND patients, compared to HC; prolonged P300 latency at the Cz site in PDD patients, compared to PDND patients; and reduced P300 amplitude at the Fz electrode site in PDND patients, compared to HC.

Conclusions

N200 and P300 component may be potential electrophysiological biomarkers of early cognitive impairment in PD patients. Future studies are needed to confirm this conclusion. Estimates of N200 and P300 component can be a valuable support for clinicians in diagnosis of early cognitive impairment in PD patients due to the simplicity and non-invasiveness of the procedure.

Available only for authorised users

Levine CB, Fahrbach KR, Siderowf AD, Estok RP, Ludensky VM, Ross SD (2003) Diagnosis and treatment of Parkinson’s disease: a systematic review of the literature. Evid Rep Technol Assess (Summ) 57:1–4

Chaudhuri KR (2016) Progression and biomarkers for Parkinson disease: merging motor with nonmotor symptoms. Neurology 87(2):128–129PubMedCrossRef

Helfrich RF, Knight RT (2019) Cognitive neurophysiology: event-related potentials. Handb Clin Neurol 160:543–558PubMedCrossRef

Woodman GF (2010) A brief introduction to the use of event-related potentials in studies of perception and attention. Atten Percept Psychophys 72(8):2031–2046PubMedCrossRef

Georgiev D, Lange F, Seer C, Kopp B, Jahanshahi M (2016) Movement-related potentials in Parkinson’s disease. Clin Neurophysiol 127(6):2509–2519PubMedCrossRef

Philipova D, Gatchev G, Vladova T, Georgiev D (1997) Event-related potentials in parkinsonian patients under auditory discrimination tasks. Int J Psychophysiol 27(1):69–78PubMedCrossRef

Weber J, Abeln V, Steichele K, Foitschik T, Stuckenschneider T. (2021) Inefficient resource allocation is associated with reduced alpha activity in parietal regions in individuals with Parkinson's disease. Eur J Neurosci 53(4):1225–37

Yilmaz FT, Özkaynak SS, Barçin E (2017) Contribution of auditory P300 test to the diagnosis of mild cognitive impairment in Parkinson's disease. Neurol Sci 38(12):2103–9

Hu P, Cao R, Fang J, Yang Q, Liu T, Yu F et al (2021) Alterations in event-related potential responses to empathy for pain in Parkinson’s disease on and off medication. Clin Neurophysiol 132(4):914–921PubMedCrossRef

10.

Solís-Vivanco R, Rodríguez-Violante M, Rodríguez-Agudelo Y, Schilmann A, Rodríguez-Ortiz U, Ricardo-Garcell J (2015) The P3a wave: a reliable neurophysiological measure of Parkinson’s disease duration and severity. Clin Neurophysiol 126(11):2142–2149PubMedCrossRef

11.

Suvorov N, Krylov I, Voilokova N (1999) Voluntary movements and event-related potentials in Parkinsonians (stages 1–2). Int J Psychophysiol 31(2):95–110PubMedCrossRef

12.

Wang L, Kuroiwa Y, Kamitani T (1999) Visual event-related potential changes at two different tasks in nondemented Parkinson’s disease. J Neurol Sci 164(2):139–147PubMedCrossRef

13.

Pekkonen E, Jousmäki V, Reinikainen K, Partanen J (1995) Automatic auditory discrimination is impaired in Parkinson’s disease. Electroencephalogr Clin Neurophysiol 95(1):47–52PubMedCrossRef

14.

Stanzione P, Semprini R, Pierantozzi M, Santilli AM, Fadda L, Traversa R et al (1998) Age and stage dependency of P300 latency alterations in non-demented Parkinson’s disease patients without therapy. Electroencephalogr Clin Neurophysiol 108(1):80–91PubMedCrossRef

15.

Antal A, Dibó G, Kéri S, Gábor K, Janka Z, Vécsei L et al (2000) P300 component of visual event-related potentials distinguishes patients with idiopathic Parkinson’s disease from patients with essential tremor. J Neural Transm (Vienna, Austria : 1996) 107(7):787–797CrossRef

16.

Bocquillon P, Bourriez JL, Palmero-Soler E, Destée A, Defebvre L, Derambure P et al (2012) Role of basal ganglia circuits in resisting interference by distracters: a swLORETA study. PLoS One 7(3):e34239PubMedPubMedCentralCrossRef

17.

Özmüş G, Yerlikaya D, Gökçeoğlu A, EmekSavaş DD, Çakmur R, DönmezÇolakoğlu B et al (2017) Demonstration of early cognitive impairment in Parkinson’s disease with visual P300 responses. Noro Psikiyatr Ars 54(1):21–27PubMedPubMedCentralCrossRef

18.

Pauletti C, Mannarelli D, Locuratolo N, Currà A, Marinelli L, Fattapposta F (2019) Central fatigue and attentional processing in Parkinson’s disease: an event-related potentials study. Clin Neurophysiol 130(5):692–700PubMedCrossRef

19.

Gaudreault PO, Gagnon JF, Montplaisir J, Vendette M, Postuma RB, Gagnon K et al (2013) Abnormal occipital event-related potentials in Parkinson’s disease with concomitant REM sleep behavior disorder. Parkinsonism Relat Disord 19(2):212–217PubMedCrossRef

20.

Wang L, Kuroiwa Y, Li M, Kamitani T, Wang J, Takahashi T et al (2000) The correlation between P300 alterations and regional cerebral blood flow in non-demented Parkinson’s disease. Neurosci Lett 282(3):133–136PubMedCrossRef

21.

Ebmeier KP, Potter DD, Cochrane RH, Crawford JR, Stewart L, Calder SA et al (1992) Event related potentials, reaction time, and cognitive performance in idiopathic Parkinson’s disease. Biol Psychol 33(1):73–89PubMedCrossRef

22.

Wang L, Kuroiwa Y, Kamitani T, Li M, Takahashi T, Suzuki Y et al (2000) Visual event-related potentials in progressive supranuclear palsy, corticobasal degeneration, striatonigral degeneration, and Parkinson’s disease. J Neurol 247(5):356–363PubMedCrossRef

23.

Antal A, Pfeiffer R, Bodis-Wollner I (1996) Simultaneously evoked primary and cognitive visual evoked potentials distinguish younger and older patients with Parkinson’s disease. J Neural Transm (Vienna) 103(8–9):1053–1067CrossRef

24.

Bokura H, Yamaguchi S, Kobayashi S (2005) Event-related potentials for response inhibition in Parkinson’s disease. Neuropsychologia 43(6):967–975PubMedCrossRef

25.

Wang L, Kuroiwa Y, Kamitani T, Takahashi T, Suzuki Y, Hasegawa O (1999) Effect of interstimulus interval on visual P300 in Parkinson’s disease. J Neurol Neurosurg Psychiatry 67(4):497–503PubMedPubMedCentralCrossRef

26.

Filipović S, Kostić VS, Sternić N, Marinković Z, Ocić G (1990) Auditory event-related potentials in different types of dementia. Eur Neurol 30(4):189–193PubMedCrossRef

27.

Tachibana H, Toda L, Sugita M (1992) Actively and passively evoked P3 latency of event-related potentials in Parkinson’s disease. J Neurol Sci 111(2):134–142PubMedCrossRef

28.

Matsui H, Nishinaka K, Oda M, Kubori T, Udaka F (2007) Auditory event-related potentials in Parkinson’s disease: prominent correlation with attention. Parkinsonism Relat Disord 13(7):394–398PubMedCrossRef

29.

Beste C, Dziobek I, Hielscher H, Willemssen R, Falkenstein M (2009) Effects of stimulus-response compatibility on inhibitory processes in Parkinson’s disease. Eur J Neurosci 29(4):855–860PubMedCrossRef

30.

Miller IN, Neargarder S, Risi MM, Cronin-Golomb A (2013) Frontal and posterior subtypes of neuropsychological deficit in Parkinson’s disease. Behav Neurosci 127(2):175–183PubMedPubMedCentralCrossRef

31.

Goldman JG, Weis H, Stebbins G, Bernard B, Goetz CG (2012) Clinical differences among mild cognitive impairment subtypes in Parkinson’s disease. Mov Disord 27(9):1129–1136PubMedPubMedCentralCrossRef

32.

Kalbe E, Rehberg SP, Heber I, Kronenbuerger M, Schulz JB, Storch A et al (2016) Subtypes of mild cognitive impairment in patients with Parkinson’s disease: evidence from the LANDSCAPE study. J Neurol Neurosurg Psychiatry 87(10):1099–1105PubMedCrossRef

33.

Pfeiffer HC, Løkkegaard A, Zoetmulder M, Friberg L, Werdelin L (2014) Cognitive impairment in early-stage non-demented Parkinson’s disease patients. Acta Neurol Scand 129(5):307–318PubMedCrossRef

34.

Williams-Gray CH, Evans JR, Goris A, Foltynie T, Ban M, Robbins TW et al (2009) The distinct cognitive syndromes of Parkinson’s disease: 5 year follow-up of the CamPaIGN cohort. Brain 132(Pt 11):2958–2969PubMedCrossRef

35.

Pal A, Pegwal N, Kaur S, Mehta N, Behari M, Sharma R (2018) Deficit in specific cognitive domains associated with dementia in Parkinson’s disease. J Clin Neurosci 57:116–120PubMedCrossRef

36.

Patel SH, Azzam PN (2005) Characterization of N200 and P300: selected studies of the Event-Related Potential. Int J Med Sci 2(4):147–154PubMedPubMedCentralCrossRef

37.

Bennys K, Portet F, Touchon J, Rondouin G (2007) Diagnostic value of event-related evoked potentials N200 and P300 subcomponents in early diagnosis of Alzheimer’s disease and mild cognitive impairment. J Clin Neurophysiol 24(5):405–412PubMedCrossRef

38.

Dong G, Zhou H, Zhao X (2010) Impulse inhibition in people with Internet addiction disorder: electrophysiological evidence from a Go/NoGo study. Neurosci Lett 485(2):138–142PubMedCrossRef

39.

Magliero A, Bashore TR, Coles MG, Donchin E (1984) On the dependence of P300 latency on stimulus evaluation processes. Psychophysiology 21(2):171–186PubMedCrossRef

40.

Fjell AM, Walhovd KB (2001) P300 and neuropsychological tests as measures of aging: scalp topography and cognitive changes. Brain Topogr 14(1):25–40PubMedCrossRef

41.

Kutas M, McCarthy G, Donchin E (1977) Augmenting mental chronometry: the P300 as a measure of stimulus evaluation time. Science 197(4305):792–795PubMedCrossRef

42.

Kramer AF, Strayer DL (1988) Assessing the development of automatic processing: an application of dual-task and event-related brain potential methodologies. Biol Psychol 26(1–3):231–267PubMedCrossRef

43.

Kramer AF, Wickens CD, Donchin E (1983) An analysis of the processing requirements of a complex perceptual-motor task. Hum Factors 25(6):597–621PubMedCrossRef

44.

Polich J (1986) P300 development from auditory stimuli. Psychophysiology 23(5):590–597PubMedCrossRef

45.

Tokic K, Titlic M, Beganovic-Petrovic A, Suljic E, Romac R, Silic S (2016) P300 wave changes in patients with Parkinson’s disease. Med Arch (Sarajevo, Bosnia and Herzegovina) 70(6):453–456

46.

Toda K, Tachibana H, Sugita M, Konishi K (1993) P300 and reaction time in Parkinson’s disease. J Geriatr Psychiatry Neurol 6(3):131–136PubMedCrossRef

47.

Piccirilli M, D’Alessandro P, Finali G, Piccinin GL, Agostini L (1989) Frontal lobe dysfunction in Parkinson’s disease: prognostic value for dementia? Eur Neurol 29(2):71–76PubMedCrossRef

48.

Taylor AE, Saint-Cyr JA, Lang AE (1990) Memory and learning in early Parkinson’s disease: evidence for a “frontal lobe syndrome.” Brain Cogn 13(2):211–232PubMedCrossRef

49.

Bès A, Güell A, Fabre N, Dupui P, Victor G, Géraud G (1983) Cerebral blood flow studied by Xenon-133 inhalation technique in parkinsonism: loss of hyperfrontal pattern. J Cereb Blood Flow Metab 3(1):33–37PubMedCrossRef

50.

Scatton B, Javoy-Agid F, Rouquier L, Dubois B, Agid Y (1983) Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson’s disease. Brain Res 275(2):321–328PubMedCrossRef

51.

Gaspar P, Duyckaerts C, Alvarez C, Javoy-Agid F, Berger B (1991) Alterations of dopaminergic and noradrenergic innervations in motor cortex in Parkinson’s disease. Ann Neurol 30(3):365–374PubMedCrossRef

52.

Stern Y, Mayeux R, Côté L (1984) Reaction time and vigilance in Parkinson’s disease Possible role of altered norepinephrine metabolism. Arch Neurol 41(10):1086–1089PubMedCrossRef

53.

Hs L, Sb D (2012) Cognitive dysfunction and depression in Parkinson’s disease: what can be learned from rodent models? Eur J Neurosci 35(12):1894–1907CrossRef

54.

Khomenko IG, Pronina MV, Kataeva GV, Kropotov JD, Irishina YA, Susin DS (2020) Combined 18F-fluorodeoxyglucose positron emission tomography and event-related potentials study of the cognitive impairment mechanisms in Parkinson’s disease. J Clin Neurosci 72:335–341PubMedCrossRef

55.

Picco A, Morbelli S, Piccardo A, Arnaldi D, Girtler N, Brugnolo A et al (2015) Brain (18)F-DOPA PET and cognition in de novo Parkinson’s disease. Eur J Nucl Med Mol Imaging 42(7):1062–1070PubMedCrossRef

56.

Tanaka H, Koenig T, Pascual-Marqui RD, Hirata K, Kochi K, Lehmann D (2000) Event-related potential and EEG measures in Parkinson’s disease without and with dementia. Dement Geriatr Cogn Disord 11(1):39–45PubMedCrossRef

57.

Hansch EC, Syndulko K, Cohen SN, Goldberg ZI, Potvin AR, Tourtellotte WW (1982) Cognition in Parkinson disease: an event-related potential perspective. Ann Neurol 11(6):599–607PubMedCrossRef

58.

Folstein JR, Van Petten C (2008) Influence of cognitive control and mismatch on the N2 component of the ERP: a review. Psychophysiology 45(1):152–170PubMed

59.

Nieuwenhuis S, Yeung N, van den Wildenberg W, Ridderinkhof KR (2003) Electrophysiological correlates of anterior cingulate function in a go/no-go task: effects of response conflict and trial type frequency. Cogn Affect Behav Neurosci 3(1):17–26PubMedCrossRef

60.

Sutton S, Braren M, Zubin J, John ER (1965) Evoked-potential correlates of stimulus uncertainty. Science 150(3700):1187–1188PubMedCrossRef

61.

Picton TW (1992) The P300 wave of the human event-related potential. J Clin Neurophysiol 9(4):456–479PubMedCrossRef

62.

Seer C, Lange F, Georgiev D, Jahanshahi M, Kopp B (2016) Event-related potentials and cognition in Parkinson’s disease: an integrative review. Neurosci Biobehav Rev 71:691–714PubMedCrossRef

63.

Polich J, Corey-Bloom J (2005) Alzheimer’s disease and P300: review and evaluation of task and modality. Curr Alzheimer Res 2(5):515–525PubMedCrossRef

64.

Litvan I, Aarsland D, Adler CH, Goldman JG, Kulisevsky J, Mollenhauer B et al (2011) MDS Task Force on mild cognitive impairment in Parkinson’s disease: critical review of PD-MCI. Mov Disord 26(10):1814–1824PubMedPubMedCentralCrossRef

Title: N200 and P300 component changes in Parkinson’s disease: a meta-analysis
Authors: Hui Xu
Lihua Gu
Shiyao Zhang
Yuchen Wu
Xiaojin Wei
Caiyan Wang
Yuhan Xu
Yijing Guo
Publication date: 18-08-2022
Publisher: Springer International Publishing
Keywords: Dementia
Parkinson's Disease
Dementia
Published in: Neurological Sciences / Issue 12/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-06348-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

N200 and P300 component changes in Parkinson’s disease: a meta-analysis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 12/2022

Sensory-motor not length-dependent multineuropathy followed by the syringomyelia-like phenotype: a novel presentation of Tangier disease

Cutaneous silent period in ATTRv carriers: a possible early marker of nerve damage?

Trends of recanalization therapies and state of art for ischemic stroke treatment in Campania region, Italy

Giant cell arteritis with amaurosis and bilateral mydriasis in the emergency room: a case report and literature review

Favorable outcome of partial splenic embolization after thrombolysis-induced splenic rupture following ischemic stroke: a case report

Correction to: The Italian tremor Network (TITAN): rationale, design and preliminary findings