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Published in: Neurological Sciences 1/2021

01-01-2021 | Dementia | Brief Communication

Analysis of the LRP10 gene in patients with Parkinson’s disease and dementia with Lewy bodies from Southern Italy

Authors: Monica Gagliardi, Radha Procopio, Giuseppe Nicoletti, Maurizio Morelli, Marco D’Amelio, Aldo Quattrone, Grazia Annesi

Published in: Neurological Sciences | Issue 1/2021

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Abstract

Recently, the LRP10 gene has been associated with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), and dementia with Lewy bodies (DLB). The aim of the present study was to evaluate the presence of mutations of the LRP10 gene in patients with PD or DLB from Southern Italy. Sequencing analysis revealed only 2 missense and 3 synonymous variants in patients and control subjects and a rare variant p.L622F in a PD case. These results suggest that LRP10 mutations are not a frequent cause of PD and DLB in Southern Italy.
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Metadata
Title
Analysis of the LRP10 gene in patients with Parkinson’s disease and dementia with Lewy bodies from Southern Italy
Authors
Monica Gagliardi
Radha Procopio
Giuseppe Nicoletti
Maurizio Morelli
Marco D’Amelio
Aldo Quattrone
Grazia Annesi
Publication date
01-01-2021
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 1/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-020-04747-1

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