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03-05-2023 | Dementia | Original Communication

Decreased aperiodic neural activity in Parkinson’s disease and dementia with Lewy bodies

Authors: Yevgenia Rosenblum, Tamara Shiner, Noa Bregman, Nir Giladi, Inbal Maidan, Firas Fahoum, Anat Mirelman

Published in: Journal of Neurology | Issue 8/2023

Abstract

Neural oscillations and signal complexity have been widely studied in neurodegenerative diseases, whereas aperiodic activity has not been explored yet in those disorders. Here, we assessed whether the study of aperiodic activity brings new insights relating to disease as compared to the conventional spectral and complexity analyses. Eyes-closed resting-state electroencephalography (EEG) was recorded in 21 patients with dementia with Lewy bodies (DLB), 28 patients with Parkinson’s disease (PD), 27 patients with mild cognitive impairment (MCI) and 22 age-matched healthy controls. Spectral power was differentiated into its oscillatory and aperiodic components using the Irregularly Resampled Auto-Spectral Analysis. Signal complexity was explored using the Lempel–Ziv algorithm (LZC). We found that DLB patients showed steeper slopes of the aperiodic power component with large effect sizes compared to the controls and MCI and with a moderate effect size compared to PD. PD patients showed steeper slopes with a moderate effect size compared to controls and MCI. Oscillatory power and LZC differentiated only between DLB and other study groups and were not sensitive enough to detect differences between PD, MCI, and controls. In conclusion, both DLB and PD are characterized by alterations in aperiodic dynamics, which are more sensitive in detecting disease-related neural changes than the traditional spectral and complexity analyses. Our findings suggest that steeper aperiodic slopes may serve as a marker of network dysfunction in DLB and PD features.

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Title: Decreased aperiodic neural activity in Parkinson’s disease and dementia with Lewy bodies
Authors: Yevgenia Rosenblum
Tamara Shiner
Noa Bregman
Nir Giladi
Inbal Maidan
Firas Fahoum
Anat Mirelman
Publication date: 03-05-2023
Publisher: Springer Berlin Heidelberg
Keywords: Dementia
Electroencephalography
Parkinson's Disease
Dementia
Mild Neurocognitive Disorder
Published in: Journal of Neurology / Issue 8/2023
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-023-11728-9

2024 ASCO Annual Meeting

Springer Medicine

Decreased aperiodic neural activity in Parkinson’s disease and dementia with Lewy bodies

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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