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01-08-2010 | Original Research Article

Deactivation of the rod response in retinopathy of prematurity

Authors: Ronald M. Hansen, Maureen E. Harris, Anne Moskowitz, Anne B. Fulton

Published in: Documenta Ophthalmologica | Issue 1/2010

Abstract

It is known that retinopathy of prematurity (ROP) alters the activation of rod photoreceptors, but the effect of ROP on deactivation has not been investigated. We studied deactivation using an electroretinographic (ERG) paired flash procedure in 22 subjects (12 infants and 10 older subjects) with a history of preterm birth and ROP. The amplitude of the rod-isolated a-wave response to a flash presented 2–120 s after a test flash was measured, and the time at which it reached 50% of the single flash amplitude (t ₅₀) was determined by linear interpolation. Deactivation results were compared to those in former preterms who never had ROP (n = 6) and term-born controls. In infants, t ₅₀ values of ROP subjects did not differ from those in subjects who never had ROP or term-born controls. Among mature ROP subjects, eight of 12 had t ₅₀ values longer than any control subject. Prolonged deactivation in these mature ROP subjects may indicate lack of maturation of the deactivation process (t ₅₀) or progressive compromise of retinal function with increasing age.

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Title: Deactivation of the rod response in retinopathy of prematurity
Authors: Ronald M. Hansen
Maureen E. Harris
Anne Moskowitz
Anne B. Fulton
Publication date: 01-08-2010
Publisher: Springer-Verlag
Published in: Documenta Ophthalmologica / Issue 1/2010
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-010-9228-z

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Deactivation of the rod response in retinopathy of prematurity

Abstract

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