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01-10-2009 | Original Article

Dantrolene can reduce secondary damage after spinal cord injury

Authors: Adem Aslan, Mustafa Cemek, Mehmet Emin Buyukokuroglu, Korhan Altunbas, Orhan Bas, Yusuf Yurumez, Murat Cosar

Published in: European Spine Journal | Issue 10/2009

Abstract

The aim of this experimental study was to investigate the possible protective effects of dantrolene on traumatic spinal cord injury (SCI). Twenty-four New Zealand rabbits were divided into three groups: Sham (no drug or operation, n = 8), Control (SCI + 1 mL saline intraperitoneally (i.p.), n = 8), and DNT (SCI + 10 mg/kg dantrolene in 1 mL, i.p., n = 8). Laminectomy was performed at T10 and balloon catheter was applied extradurally. Four and 24 h after surgery, rabbits were evaluated according to the Tarlov scoring system. Blood, cerebrospinal fluid and tissue sample from spinal cord were taken for measurements of antioxidant status or detection of apoptosis. After 4 h SCI, all animals in control or DNT-treated groups became paraparesic. Significant improvement was observed in DNT-treated group, 24 h after SCI, with respect to control. Traumatic SCI led to an increase in the lipid peroxidation and a decrease in enzymic or non-enzymic endogenous antioxidative defense systems, and increase in apoptotic cell numbers. DNT treatment prevented lipid peroxidation and augmented endogenous enzymic or non-enzymic antioxidative defense systems. Again, DNT treatment significantly decreased the apoptotic cell number induced by SCI. In conclusion, experimental results observed in this study suggest that treatment with dantrolene possess potential benefits for traumatic SCI.

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Title: Dantrolene can reduce secondary damage after spinal cord injury
Authors: Adem Aslan
Mustafa Cemek
Mehmet Emin Buyukokuroglu
Korhan Altunbas
Orhan Bas
Yusuf Yurumez
Murat Cosar
Publication date: 01-10-2009
Publisher: Springer-Verlag
Published in: European Spine Journal / Issue 10/2009
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-009-1033-6

At a glance: The STEP trials

Springer Medicine

Dantrolene can reduce secondary damage after spinal cord injury

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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