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18-01-2024 | Cytokines | Correspondence

Subphenotypes in critical illness: a priori biological rationale is key. Author’s reply

Authors: Jie Yang, Jiajie Huang, Yucai Hong, Zhongheng Zhang, for the CMAISE consortium

Published in: Intensive Care Medicine | Issue 2/2024

Excerpt

We appreciate the interests from members of the MARS consortium in our work [1] and the insightful comments they have provided [2]. And we really agree on their comments that the biological rationale is the key for clustering sepsis patients. However, we would like to take the opportunity to express our views on the work. …

Zhang Z, Chen L, Liu X, Yang J, Huang J, Yang Q, Hu Q, Jin K, Celi LA, Hong Y (2023) Exploring disease axes as an alternative to distinct clusters for characterizing sepsis heterogeneity. Intensive Care Med 49:1349–1359CrossRefPubMed

van Amstel RBE, Cremer OL, van Vught LA, Bos LDJ, the MARS consortium (2023) Subphenotypes in critical illness: a priori biological rationale is key. Intensive Care Med. https://doi.org/10.1007/s00134-023-07273-8CrossRefPubMedPubMedCentral

Mittermaier M, Raza MM, Kvedar JC (2023) Bias in AI-based models for medical applications: challenges and mitigation strategies. NPJ Digit Med 6:113CrossRefPubMedPubMedCentral

Scicluna BP, van Vught LA, Zwinderman AH et al (2017) Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study. Lancet Respir Med 5:816–826CrossRefPubMed

Title: Subphenotypes in critical illness: a priori biological rationale is key. Author’s reply
Authors: Jie Yang
Jiajie Huang
Yucai Hong
Zhongheng Zhang
for the CMAISE consortium
Publication date: 18-01-2024
Publisher: Springer Berlin Heidelberg
Keyword: Cytokines
Published in: Intensive Care Medicine / Issue 2/2024
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-023-07316-0

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Subphenotypes in critical illness: a priori biological rationale is key. Author’s reply

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