Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Gastroenterology
Published in: BMC Gastroenterology 1/2023

Open Access 01-12-2023 | Cytokines | Research

Correlation between color doppler flow pattern and molecular biology in elderly patients with colon cancer

Authors: Fei Shao, Xiuxiu Lai, Lulu Tong, Linxiao Li, Da Ye, Linlin Jin, Chunyan Xu

Published in: BMC Gastroenterology | Issue 1/2023

Login to get access

Abstract

Objective

To investigate the correlation between the grade and type of color Doppler flow imaging (CDFI) and tumor-related cytokines in elderly patients with colon cancer.

Methods

Seventy-six elderly patients with colorectal cancer admitted to Zhejiang Provincial People’s Hospital from July 2020 to June 2022 were selected. CDFI was used to analyze the blood flow grade and distribution type of tumor tissues, and ELISA was used to detect the levels of tumor-related cytokines in serum. Preoperative clinical data were collected and analyzed, and the correlation between measured cytokine levels and CDFI analysis results was further explored.

Results

CDFI blood flow grade showed significant difference in the different lengths, invasion depths and lymph node metastasis of tumors (all P < 0.001). In addition, serum levels of TNF-α, IL-6 and VEGF also showed statistical difference in all above different tumor-related factors (all P < 0.001). Further Pearson correlation analysis showed that CDFI blood flow grade and distribution types were both significantly positively correlated with above serum cytokine levels (r > 0, all P < 0.001). Kaplan-Meier survival analysis showed that both CDFI blood flow grade and distribution types were poor prognostic factors in elderly patients with colon cancer. Regression analysis showed that serum levels of TNF-α, IL-6 and VEGF were independent risk factors for poor prognosis of colon cancer in elderly patients.

Conclusion

CDFI blood flow grade and tumor tissue distribution have potential significant correlations with tumor-associated cytokines in the serum of colon cancer patients. CDFI blood flow grading technique provides an important imaging method for dynamic observation of angiogenesis and blood flow changes in elderly patients with colon cancer. Abnormal changes in serum levels of tumor-related factors can be used as sensitive indicators to evaluate the therapeutic effect and prognosis of colon cancer.
Literature
1.
Su Y, Tian X, Gao R, Guo W, Chen C, Chen C, et al. Colon cancer diagnosis and staging classification based on machine learning and bioinformatics analysis. Comput Biol Med. 2022;145:105409.CrossRefPubMed
2.
3.
González NS, Ros Montaña FJ, Illescas DG, Argota IB, Ballabrera FS, Élez Fernández ME. New Insights into Adjuvant Therapy for localized Colon cancer. Hematol Oncol Clin N Am. 2022;36(3):507–20.CrossRef
4.
Fabregas JC, Ramnaraign B, George TJ. Clinical updates for Colon Cancer Care in 2022. Clin Colorectal Cancer. 2022;21(3):198–203.CrossRefPubMed
5.
Chuang JP, Tsai HL, Chen PJ, Chang TK, Su WC, Yeh YS, et al. Comprehensive review of biomarkers for the treatment of locally advanced Colon cancer. Cells. 2022;11(23):3744.CrossRefPubMedPubMedCentral
6.
Shinji S, Yamada T, Matsuda A, Sonoda H, Ohta R, Iwai T, et al. Recent advances in the treatment of Colorectal Cancer: a review. J Nippon Med School = Nippon Ika Daigaku zasshi. 2022;89(3):246–54.CrossRefPubMed
7.
Maoz A, Dennis M, Greenson JK. The Crohn’s-Like lymphoid reaction to Colorectal Cancer-Tertiary lymphoid structures with immunologic and potentially therapeutic relevance in Colorectal Cancer. Front Immunol. 2019;10:1884.CrossRefPubMedPubMedCentral
8.
Zlobec I, Bihl MP, Foerster A, Rufle A, Terracciano L, Lugli A. Stratification and prognostic relevance of Jass’s Molecular classification of Colorectal Cancer. Front Oncol. 2012;2:7.CrossRefPubMedPubMedCentral
9.
Uludag SS, Sanli AN, Zengin AK, Ozcelik MF. Systemic inflammatory biomarkers as surrogate markers for stage in Colon cancer. Am Surg. 2022;88(6):1256–62.CrossRefPubMed
10.
Farzaneh Behelgardi M, Gholami Shahvir Z, Asghari SM. Apoptosis induction in human lung and colon cancer cells via impeding VEGF signaling pathways. Mol Biol Rep. 2022;49(5):3637–47.CrossRefPubMed
11.
Zhou J, Wang L, Peng C, Peng F. Co-targeting Tumor Angiogenesis and Immunosuppressive Tumor Microenvironment: a perspective in Ethnopharmacology. Front Pharmacol. 2022;13:886198.CrossRefPubMedPubMedCentral
12.
Rudno-Rudzińska J, Kielan W, Frejlich E, Kotulski K, Hap W, Kurnol K, et al. A review on Eph/ephrin, angiogenesis and lymphangiogenesis in gastric, colorectal and pancreatic cancers. Chin J cancer research = Chung-kuo yen cheng yen chiu. 2017;29(4):303–12.CrossRef
13.
Wali RK, Roy HK, Kim YL, Liu Y, Koetsier JL, Kunte DP, et al. Increased microvascular blood content is an early event in colon carcinogenesis. Gut. 2005;54(5):654–60.CrossRefPubMedPubMedCentral
14.
Valuckaite V, Ruderman S, Almoghrabi A, Hart J, Abdyrakov A, Roy HK, et al. A novel use of angiotensin II receptor blocker (ARB) Losartan to inhibit AOM Induced Tumorigenesis and Neoangiogenesis in experimental Colon cancer. Gastroenterology. 2015;148(4):–172.
15.
Tiwari AK, Crawford SE, Radosevich A, Wali RK, Stypula Y, Kunte DP, et al. Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis. Cancer Lett. 2011;306(2):205–13.CrossRefPubMedPubMedCentral
16.
Mao Y, Mu J, Zhao J, Yang F, Zhao L. The comparative study of color doppler flow imaging, superb microvascular imaging, contrast-enhanced ultrasound micro flow imaging in blood flow analysis of solid renal mass. Cancer imaging: the official publication of the International Cancer Imaging Society. 2022;22(1):21.CrossRefPubMed
17.
Aziz MU, Eisenbrey JR, Deganello A, Zahid M, Sharbidre K, Sidhu P, et al. Microvascular Flow Imaging: a state-of-the-art review of clinical Use and Promise. Radiology. 2022;305(2):250–64.CrossRefPubMed
18.
Mittal A, Anand R, Gauba R, Choudhury SR, Abbey P. A step-by-step Sonographic Approach to Vascular Anomalies in the Pediatric Population: a pictorial essay. Indian J Radiol Imaging. 2021;31(1):157–71.PubMedPubMedCentral
19.
20.
Zhang D, Wang Y, Yang F, Mao Y, Mu J, Zhao L et al. Diagnostic value of Multi-Mode Ultrasonic Flow Imaging examination in solid renal tumors of different sizes. J Clin Med. 2023;12(2).
21.
Zhao L, Mao Y, Mu J, Zhao J, Li F, Zhang S, et al. The diagnostic value of superb microvascular imaging in identifying benign tumors of parotid gland. BMC Med Imaging. 2020;20(1):107.CrossRefPubMedPubMedCentral
22.
23.
da Silva DC, Orfali GDC, Santana MG, Palma JKY, Assunção IRO, Marchesi IM, et al. Antitumor effect of isoquercetin on tissue vasohibin expression and colon cancer vasculature. Oncotarget. 2022;13:307–18.CrossRefPubMedPubMedCentral
24.
Chen CN, Cheng YM, Liang JT, Lee PH, Hsieh FJ, Yuan RH, et al. Color Doppler vascularity index can predict distant metastasis and survival in colon cancer patients. Cancer Res. 2000;60(11):2892–7.PubMed
25.
Li ZP, Meng QF, Sun CH, Xu DS, Fan M, Yang XF, et al. Tumor angiogenesis and dynamic CT in colorectal carcinoma: radiologic-pathologic correlation. World J Gastroenterol. 2005;11(9):1287–91.CrossRefPubMedPubMedCentral
26.
Takebayashi Y, Aklyama S, Yamada K, Akiba S, Aikou T. Angiogenesis as an unfavorable prognostic factor in human colorectal carcinoma. Cancer. 1996;78(2):226–31.CrossRefPubMed
27.
Stockmann C, Schadendorf D, Klose R, Helfrich I. The impact of the immune system on tumor: angiogenesis and vascular remodeling. Front Oncol. 2014;4:69.CrossRefPubMedPubMedCentral
28.
Hida K, Maishi N, Torii C, Hida Y. Tumor angiogenesis–characteristics of tumor endothelial cells. Int J Clin Oncol. 2016;21(2):206–12.CrossRefPubMed
29.
Siveen KS, Prabhu K, Krishnankutty R, Kuttikrishnan S, Tsakou M, Alali FQ, et al. Vascular endothelial growth factor (VEGF) signaling in Tumour Vascularization: potential and Challenges. Curr Vasc Pharmacol. 2017;15(4):339–51.CrossRefPubMed
30.
31.
Harrison ML, Obermueller E, Maisey NR, Hoare S, Edmonds K, Li NF, et al. Tumor necrosis factor alpha as a new target for renal cell carcinoma: two sequential phase II trials of infliximab at standard and high dose. J Clin oncology: official J Am Soc Clin Oncol. 2007;25(29):4542–9.CrossRef
32.
Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci. 2012;8(9):1237–47.CrossRefPubMedPubMedCentral
33.
Shang GS, Liu L, Qin YW. IL-6 and TNF-alpha promote metastasis of lung cancer by inducing epithelial-mesenchymal transition. Oncol Lett. 2017;13(6):4657–60.CrossRefPubMedPubMedCentral
34.
Kang Y, Li S, Ge Q, Liu X, Yang Z, Xue Y, et al. Extent of Serosal Changes predicts peritoneal recurrence and poor prognosis after curative surgery for gastric Cancer. Med (Baltim). 2015;94(42):e1750.CrossRef
35.
Al-Obaidy KI, Idrees MT, Abdulfatah E, Kunju LP, Wu A, Ulbright TM. Large cell calcifying sertoli cell tumor: a clinicopathologic study of 18 cases with Comprehensive Review of the literature and reappraisal of Prognostic features. Am J Surg Pathol. 2022;46(5):688–700.CrossRefPubMed
36.
Watanabe T, Kaoku S, Yamaguchi T, Izumori A, Konno S, Okuno T, et al. Multicenter prospective study of Color Doppler Ultrasound for breast masses: utility of our Color Doppler Method. Ultrasound Med Biol. 2019;45(6):1367–79.CrossRefPubMed
37.
Xu L, Tavora F, Burke A. Histologic features associated with metastatic potential in invasive adenocarcinomas of the lung. Am J Surg Pathol. 2013;37(7):1100–8.CrossRefPubMed
Metadata
Title
Correlation between color doppler flow pattern and molecular biology in elderly patients with colon cancer
Authors
Fei Shao
Xiuxiu Lai
Lulu Tong
Linxiao Li
Da Ye
Linlin Jin
Chunyan Xu
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2023
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-023-02870-9

Other articles of this Issue 1/2023

BMC Gastroenterology 1/2023 Go to the issue

Research

Regular use of low-dose of opioids after gastrointestinal surgery may lead to postoperative gastrointestinal tract dysfunction in children: a Chinese national regional health center experience sharing

Research

Safe discharge for patients admitted for lower gastrointestinal bleeding (LGITB): derivation and validation of a novel scoring system

Correction

Correction: Extracellular matrix remodeling proteins as biomarkers for clinical assessment and treatment outcomes in eosinophilic esophagitis

Research

Magnetic-controlled capsule endoscopy performance in aging patients

Research

Effectiveness of betadine-coating gastrostomy tube to reduce peristomal infection after percutaneous endoscopic gastrostomy: a randomized controlled trial

Research

Comprehensive analysis of candidate signatures of long non-coding RNA LINC01116 and related protein-coding genes in patients with hepatocellular carcinoma
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits