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Journal of Cancer Research and Clinical Oncology

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01-04-2015 | Review – Cancer Research

Cytokines: shifting the balance between glioma cells and tumor microenvironment after irradiation

Authors: Wei Zhou, Zheng Jiang, Xingang Li, Yangyang Xu, Zhenyu Shao

Published in: Journal of Cancer Research and Clinical Oncology | Issue 4/2015

Abstract

Malignant gliomas invariably recur after irradiation, showing radioresistance. Meanwhile, cranial irradiation can bring some risk for developing cognitive dysfunction. There is increasing evidence that cytokines play their peculiar roles in these processes. On the one hand, cytokines directly influence the progression of malignant glioma, promoting or suppressing tumor progression. On the other hand, cytokines indirectly contribute to the immunologic response against gliomas, exhibiting pro-inflammatory or immunosuppressive activities. We propose that cytokines are not simply unregulated products from tumor cells or immune cells, but mediators finely adjust the balance between glioma cells and tumor microenvironment after irradiation. The paper, therefore, focuses on the changes of cytokines after irradiation, analyzing how these mediate the response of tumor cells and normal cells to irradiation. In addition, cytokine-based immunotherapeutic strategies, accompanied with irradiation, for the treatment of gliomas are also discussed.

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Title: Cytokines: shifting the balance between glioma cells and tumor microenvironment after irradiation
Authors: Wei Zhou
Zheng Jiang
Xingang Li
Yangyang Xu
Zhenyu Shao
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Journal of Cancer Research and Clinical Oncology / Issue 4/2015
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-014-1772-6

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