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European Journal of Epidemiology
Published in: European Journal of Epidemiology 7/2010

01-07-2010 | CANCER

CYP1A2 polymorphisms, occupational and environmental exposures and risk of bladder cancer

Authors: Sofia Pavanello, Giuseppe Mastrangelo, Donatella Placidi, Marcello Campagna, Alessandra Pulliero, Angela Carta, Cecilia Arici, Stefano Porru

Published in: European Journal of Epidemiology | Issue 7/2010

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Abstract

Cytochrome P4501A2 (CYP1A2) is a key enzyme for activation of bladder carcinogens. Polymorphisms in the 5′-noncoding promoter region of CYP1A2 gene [mainly −2467T/delT(rs35694136) and −163C/A(rs762551)], are crucial in modifying CYP1A2 activity in smokers. Within the framework of a hospital-based case/control study, we investigated the relationship between CYP1A2 polymorphisms, occupational/environmental exposures and bladder cancer (BC) risk. The study population included 185 BC cases and 180 non-cancer controls, all Caucasian males. Data were collected on lifetime smoking, coffee drinking, dietary habits and lifetime occupation, with particular reference to exposure to aromatic amines (AAs) and polycyclic aromatic hydrocarbons (PAHs). A case-only design was applied to study the interaction between CYP1A2 −2467T/delT (or −163C/A) and occupational and environmental factors. Multiple logistic regression showed a significantly increased risk among heavy smokers (≥50 packyears; OR 5.6, 95% CI: 2.5–12.5) and heavy coffee drinkers (>5 cups/day; OR 3.1, 95% CI: 1.2–7.9). Exposure to AAs showed a significant trend of BC risk with increasing cumulative exposure (CE) (P = 0.04), with heavy smoking as possible confounder. A decreased risk was noted for large leaf vegetable consumption, with significant trend from <1/month to >3 times/week (P = 0.008). The case-only analysis showed an interaction between −2467T/delT and tobacco smoking >25 packyears (P = 0.04); no interaction was detected between such polymorphisms and coffee consumption, dietary habits and occupational exposure to AAs. No effects were shown with −163C/A genotype as well as no overall effect of CYP1A2 by itself on BC risk. This is the first study suggesting that CYP1A2 −2467T/delT modifies the effect of cigarette smoking on BC risk.
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Metadata
Title
CYP1A2 polymorphisms, occupational and environmental exposures and risk of bladder cancer
Authors
Sofia Pavanello
Giuseppe Mastrangelo
Donatella Placidi
Marcello Campagna
Alessandra Pulliero
Angela Carta
Cecilia Arici
Stefano Porru
Publication date
01-07-2010
Publisher
Springer Netherlands
Published in
European Journal of Epidemiology / Issue 7/2010
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-010-9479-8

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