Skip to main content
Top
Published in: BMC Pediatrics 1/2020

Open Access 01-12-2020 | Cyanosis | Case report

COVID-19-associated apnea and circumoral cyanosis in a 3-week-old

Authors: Joseph S. Needleman, Amy E. Hanson

Published in: BMC Pediatrics | Issue 1/2020

Login to get access

Abstract

Background

Data regarding coronavirus disease 2019 (COVID-19) cases and outcomes in infants are sparse compared to older pediatric and adult populations.

Case presentation

We present a three-week-old full-term male with a history of mild hypoxic ischemic encephalopathy (HIE) who was admitted as an inpatient twice for episodes of apnea and perioral cyanosis. The patient tested positive for COVID-19 and negative for other common respiratory viruses at both admissions.

Conclusions

To our knowledge, this is the first report of apnea and perioral cyanosis associated with COVID-19 in an infant. This case highlights a previously undocumented COVID-19 presentation and suggests that even mildly symptomatic infants warrant viral diagnostic testing in an effort to prevent further spread of the disease.
Literature
1.
go back to reference Procianoy RS, Silveira RC, Manzoni P, Sant'Anna G. Neonatal COVID-19: little evidence and the need for more information. J Pediatr (Rio J). 2020;96(3):269–72. Procianoy RS, Silveira RC, Manzoni P, Sant'Anna G. Neonatal COVID-19: little evidence and the need for more information. J Pediatr (Rio J). 2020;96(3):269–72.
2.
go back to reference Morand A, Fabre A, Minodier P, et al. COVID-19 virus and children: what do we know? Arch Pediatr. 2020 Apr;27(3):117–8.CrossRef Morand A, Fabre A, Minodier P, et al. COVID-19 virus and children: what do we know? Arch Pediatr. 2020 Apr;27(3):117–8.CrossRef
5.
go back to reference Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19. An overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J. 2020 May;39(5):355–68.CrossRef Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19. An overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J. 2020 May;39(5):355–68.CrossRef
6.
go back to reference Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020. https://doi.org/10.1001/jama.2020.2648 [Epub ahead of print]. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020. https://​doi.​org/​10.​1001/​jama.​2020.​2648 [Epub ahead of print].
7.
go back to reference Lu X, Zhang L, Du H, et al. SARS-CoV-2 infection in children. N Engl J Med. 2020;382(17):1663–5.CrossRef Lu X, Zhang L, Du H, et al. SARS-CoV-2 infection in children. N Engl J Med. 2020;382(17):1663–5.CrossRef
9.
go back to reference Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020 Mar 7;395(10226):809–15.CrossRef Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020 Mar 7;395(10226):809–15.CrossRef
13.
go back to reference Tieder JS, Bonkowsky JL, Etzel RA, et al. Subcommittee on Apparent Life Threatening Events. Clinical Practice Guideline: Brief Resolved Unexplained Events (Formerly Apparent Life-Threatening Events) and Evaluation of Lower-Risk Infants. Pediatrics. 2016;137(5):e20160590.CrossRef Tieder JS, Bonkowsky JL, Etzel RA, et al. Subcommittee on Apparent Life Threatening Events. Clinical Practice Guideline: Brief Resolved Unexplained Events (Formerly Apparent Life-Threatening Events) and Evaluation of Lower-Risk Infants. Pediatrics. 2016;137(5):e20160590.CrossRef
Metadata
Title
COVID-19-associated apnea and circumoral cyanosis in a 3-week-old
Authors
Joseph S. Needleman
Amy E. Hanson
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2020
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-020-02282-8

Other articles of this Issue 1/2020

BMC Pediatrics 1/2020 Go to the issue