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Journal of Cardiovascular Translational Research

Published in:

01-10-2013

CXCR4⁺ and FLK-1⁺ Identify Circulating Cells Associated with Improved Cardiac Function in Patients Following Myocardial Infarction

Authors: Rahul Suresh, Anca Chiriac, Kashish Goel, Hector R. Villarraga, Francisco Lopez-Jimenez, Randal J. Thomas, Andre Terzic, Timothy J. Nelson, Carmen Perez-Terzic

Published in: Journal of Cardiovascular Translational Research | Issue 5/2013

Abstract

The biomarkers CXCR4/FLK-1 select cardiac progenitors from a stem cell pool in experimental models. However, the translational value of these cells in human ischemic heart disease is unknown. Here, flow-cytometry identified CD45⁻/CXCR4⁺/FLK-1⁺ cells in 30 individuals without ischemic heart disease and 33 first-time acute myocardial infarction (AMI) patients. AMI patients had higher CD45⁻/CXCR4⁺/FLK-1⁺ cell-load at 48-h and 3- and 6-months post-AMI (p = 0.003,0.04,0.04, respectively) than controls. Cardiovascular risk factors and left ventricular (LV) ejection fraction were not associated with cell-load. 2D-speckle-tracking strain echocardiography assessment of LV systolic function showed improvement in longitudinal strain and dyssynchrony during follow-up associated with longitudinal increases in and higher 48-h post-AMI CD45⁻/CXCR4⁺/FLK-1⁺ cell-load (r = −0.525, p = 0.025; r = −0.457, p = 0.029, respectively). In conclusion, CD45⁻/CXCR4⁺/FLK-1⁺ cells are present in adult human circulation, increased in AMI and associated with improved LV systolic function. Thus, CD45⁻/CXCR4⁺/FLK-1⁺ cells may provide a diagnostic tool to follow cardiac regenerative capacity and potentially serve as a prognostic marker in AMI.

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Title: CXCR4+ and FLK-1+ Identify Circulating Cells Associated with Improved Cardiac Function in Patients Following Myocardial Infarction
Authors: Rahul Suresh
Anca Chiriac
Kashish Goel
Hector R. Villarraga
Francisco Lopez-Jimenez
Randal J. Thomas
Andre Terzic
Timothy J. Nelson
Carmen Perez-Terzic
Publication date: 01-10-2013
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 5/2013
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-013-9502-z

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CXCR4⁺ and FLK-1⁺ Identify Circulating Cells Associated with Improved Cardiac Function in Patients Following Myocardial Infarction

Abstract

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Abstract

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