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Published in: Journal of Cardiovascular Translational Research 5/2013

01-10-2013

Biological Imaging of Atherosclerosis: Moving Beyond Anatomy

Authors: Johan W. Verjans, Farouc A. Jaffer

Published in: Journal of Cardiovascular Translational Research | Issue 5/2013

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Abstract

Biological or molecular imaging is now providing exciting new strategies to study atherosclerosis in both animals and humans. These technologies hold the promise to provide disease-specific, molecular information within the context of a systemic or organ-specific disease beyond traditional anatomical-based imaging. By integration of biological, chemical, and anatomical imaging knowledge into diagnostic strategies, a more comprehensive and predictive picture of atherosclerosis is likely to emerge. As such, biological imaging is well positioned to study different stages of atherosclerosis and its treatment, including the sequence of atheroma initiation, progression, and plaque rupture. In this review, we describe the evolving concepts in atherosclerosis imaging with a focus on coronary artery disease, and we provide an overview of recent exciting translational developments in biological imaging. The illuminated examples and discussions will highlight how biological imaging is providing new clinical approaches to identify high-risk plaques, and to streamline the development process of new atherosclerosis therapies.
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Metadata
Title
Biological Imaging of Atherosclerosis: Moving Beyond Anatomy
Authors
Johan W. Verjans
Farouc A. Jaffer
Publication date
01-10-2013
Publisher
Springer US
Published in
Journal of Cardiovascular Translational Research / Issue 5/2013
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-013-9474-z

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