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Esophagus
Published in: Esophagus 1/2018

01-01-2018 | Review Article

Current status of cancer immunotherapy for esophageal squamous cell carcinoma

Authors: Koji Kono, Kousaku Mimura, Reo Yamada, Daisuke Ujiie, Suguru Hayase, Takeshi Tada, Hiroyuki Hanayama, Aung Kyi Thar Min, Masahiko Shibata, Tomoyuki Momma, Zenichirou Saze, Shinji Ohki

Published in: Esophagus | Issue 1/2018

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Abstract

Background

Immunotherapy has become a promising treatment strategy for cancer. Immune checkpoint blockade with anti-CTLA4 mAb and anti-PD-1 mAb has demonstrated clear evidence of objective responses including improved overall survival and tumor shrinkage, driving renewed enthusiasm for cancer immunotherapy in multiple cancer types including esophageal squamous cell carcinoma (ESCC). There are several clinical trials using anti-PD1 mAb for ESCC in early phases and the results are currently promising.

Results and Conclusions

In this review, recent advances in cancer immunotherapy for ESCC are discussed with particular focus on immune checkpoint inhibitors and cancer vaccine.
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Metadata
Title
Current status of cancer immunotherapy for esophageal squamous cell carcinoma
Authors
Koji Kono
Kousaku Mimura
Reo Yamada
Daisuke Ujiie
Suguru Hayase
Takeshi Tada
Hiroyuki Hanayama
Aung Kyi Thar Min
Masahiko Shibata
Tomoyuki Momma
Zenichirou Saze
Shinji Ohki
Publication date
01-01-2018
Publisher
Springer Japan
Published in
Esophagus / Issue 1/2018
Print ISSN: 1612-9059
Electronic ISSN: 1612-9067
DOI
https://doi.org/10.1007/s10388-017-0596-2

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