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Medical Microbiology and Immunology
Published in: Medical Microbiology and Immunology 2/2011

01-05-2011 | Review

Current knowledge on PB1-F2 of influenza A viruses

Authors: Andi Krumbholz, Anja Philipps, Hartmut Oehring, Katja Schwarzer, Annett Eitner, Peter Wutzler, Roland Zell

Published in: Medical Microbiology and Immunology | Issue 2/2011

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Abstract

Almost 10 years ago, an eleventh protein of influenza A viruses was discovered in a search for CD8+ T-cell epitopes. This protein was named PB1-F2 since it is encoded in the +1 reading frame of the PB1 gene segment. Various studies have shown that PB1-F2 has a pleiotropic effect: (1) The protein can induce apoptosis in a cell type-dependent manner, (2) PB1-F2 is able to promote inflammation, and (3) finally it up-regulates viral polymerase activity by its interaction with the PB1 subunit. These properties could contribute to an enhanced pathogenicity. However, the underlying mechanism is not fully understood yet. New data suggest that some effects of PB1-F2 are strain-specific and host-specific.
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Metadata
Title
Current knowledge on PB1-F2 of influenza A viruses
Authors
Andi Krumbholz
Anja Philipps
Hartmut Oehring
Katja Schwarzer
Annett Eitner
Peter Wutzler
Roland Zell
Publication date
01-05-2011
Publisher
Springer-Verlag
Published in
Medical Microbiology and Immunology / Issue 2/2011
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI
https://doi.org/10.1007/s00430-010-0176-8

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