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Published in: Acta Neurochirurgica 5/2011

01-05-2011 | Clinical Article

Cryoneurolysis for zygapophyseal joint pain: a retrospective analysis of 117 interventions

Authors: Tilman Wolter, M. Deininger, U. Hubbe, M. Mohadjer, S. Knoeller

Published in: Acta Neurochirurgica | Issue 5/2011

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Abstract

Purpose

Lumbar facet joint syndrome (LFJS) is the cause of pain in 15-54% of the patients with low-back pain. There are few studies of cryotherapy for LFJS, focusing mainly on pain scores rather than further outcome measures. The aim of the study was to determine the long-term outcome after cryoneurolysis of lumbar facet joints, looking at pain scores, pain-related impairment patient satisfaction, and pain-related anxiety/depression.

Methods

The study design was a retrospective observational study. In a 4-year period, 117 cryoneurolyses were performed in 91 patients under CT guidance in the prone position. Data from patient charts and questionnaires pre- and post-treatment were evaluated.

Results

The mean pain rating sank from 7.70 before treatment to 3.72 post treatment. In the post-interventional 3 months follow-up, this value rose to 4.22. At follow-up (mean 1.7 years, range 6-52 months), the mean visual analogue scale (VAS) was 4.99.
The pain disability index revealed statistically significant improvements in the following items: familiar and domestic duties, recreation, social activities, profession and vitally indispensable activities (p < 0.05). Hospital anxiety and depression scale (HADS) scores for depression showed a statistically significant decline after therapy, whereas scores for anxiety did not. A subgroup of patients who did not benefit from cryoneurolysis had elevated depression scores.

Conclusions

Cryoneurolysis for LFJS can lead to favourable results with sustained pain relief, amelioration of pain-related disability and reduction of depression scores.
Literature
1.
go back to reference Abbott Z, Smuck M, Haig A, Sagher O (2007) Irreversible spinal nerve injury from dorsal ramus radiofrequency neurotomy: a case report. Arch Phys Med Rehabil 88:1350–1352PubMedCrossRef Abbott Z, Smuck M, Haig A, Sagher O (2007) Irreversible spinal nerve injury from dorsal ramus radiofrequency neurotomy: a case report. Arch Phys Med Rehabil 88:1350–1352PubMedCrossRef
2.
go back to reference Andres RH, Graupner T, Barlocher CB, Augsburger A, Fandino J (2010) Laser-guided lumbar medial branch kryorhizotomy. J Neurosurg Spine 13:341–345PubMedCrossRef Andres RH, Graupner T, Barlocher CB, Augsburger A, Fandino J (2010) Laser-guided lumbar medial branch kryorhizotomy. J Neurosurg Spine 13:341–345PubMedCrossRef
3.
go back to reference Bärlocher CB, Krauss JK, Seiler RW (2003) Kryorhizotomy: an alternative technique for lumbar medial branch rhizotomy in lumbar facet syndrome. J Neurosurg 98:14–20PubMedCrossRef Bärlocher CB, Krauss JK, Seiler RW (2003) Kryorhizotomy: an alternative technique for lumbar medial branch rhizotomy in lumbar facet syndrome. J Neurosurg 98:14–20PubMedCrossRef
4.
go back to reference Basler HD, Bloem R, Casser HR, Gerbershagen HU, Griessinger N, Hankemeier U, Hesselbarth S, Lautenbacher S, Nikolaus T, Richter W, Schroter C, Weiss L (2001) A structured pain interview for geriatric patients. Schmerz 15:164–171PubMedCrossRef Basler HD, Bloem R, Casser HR, Gerbershagen HU, Griessinger N, Hankemeier U, Hesselbarth S, Lautenbacher S, Nikolaus T, Richter W, Schroter C, Weiss L (2001) A structured pain interview for geriatric patients. Schmerz 15:164–171PubMedCrossRef
5.
go back to reference Beebe TJ, Rey E, Ziegenfuss JY, Jenkins S, Lackore K, Talley NJ, Locke RG 3rd (2010) Shortening a survey and using alternative forms of prenotification: impact on response rate and quality. BMC Med Res Methodol 10:50PubMedCrossRef Beebe TJ, Rey E, Ziegenfuss JY, Jenkins S, Lackore K, Talley NJ, Locke RG 3rd (2010) Shortening a survey and using alternative forms of prenotification: impact on response rate and quality. BMC Med Res Methodol 10:50PubMedCrossRef
6.
go back to reference Birkenmaier C, Veihelmann A, Trouillier H, Hausdorf J, Devens C, Wegener B, Jansson V, von Schulze PC (2007) Percutaneous cryodenervation of lumbar facet joints: a prospective clinical trial. Int Orthop 31:525–530PubMedCrossRef Birkenmaier C, Veihelmann A, Trouillier H, Hausdorf J, Devens C, Wegener B, Jansson V, von Schulze PC (2007) Percutaneous cryodenervation of lumbar facet joints: a prospective clinical trial. Int Orthop 31:525–530PubMedCrossRef
7.
go back to reference Bogduk N (2005) A narrative review of intra-articular corticosteroid injections for low back pain. Pain Med 6:287–296PubMedCrossRef Bogduk N (2005) A narrative review of intra-articular corticosteroid injections for low back pain. Pain Med 6:287–296PubMedCrossRef
8.
go back to reference Callesen T, Bech K, Thorup J, Andersen J, Nielsen R, Roikjaer O, Kehlet H (1998) Cryoanalgesia: effect on postherniorrhaphy pain. Anesth Analg 87:896–899PubMedCrossRef Callesen T, Bech K, Thorup J, Andersen J, Nielsen R, Roikjaer O, Kehlet H (1998) Cryoanalgesia: effect on postherniorrhaphy pain. Anesth Analg 87:896–899PubMedCrossRef
9.
go back to reference Cavanaugh JM, Lu Y, Chen C, Kallakuri S (2006) Pain generation in lumbar and cervical facet joints. J Bone Joint Surg Am 88(Suppl 2):63–67PubMedCrossRef Cavanaugh JM, Lu Y, Chen C, Kallakuri S (2006) Pain generation in lumbar and cervical facet joints. J Bone Joint Surg Am 88(Suppl 2):63–67PubMedCrossRef
10.
go back to reference Cohen SP, Raja SN (2007) Pathogenesis, diagnosis, and treatment of lumbar zygapophysial (facet) joint pain. Anesthesiology 106:591–614PubMedCrossRef Cohen SP, Raja SN (2007) Pathogenesis, diagnosis, and treatment of lumbar zygapophysial (facet) joint pain. Anesthesiology 106:591–614PubMedCrossRef
11.
go back to reference Datta S, Lee M, Falco FJ, Bryce DA, Hayek SM (2009) Systematic assessment of diagnostic accuracy and therapeutic utility of lumbar facet joint interventions. Pain Physician 12:437–460PubMedCrossRef Datta S, Lee M, Falco FJ, Bryce DA, Hayek SM (2009) Systematic assessment of diagnostic accuracy and therapeutic utility of lumbar facet joint interventions. Pain Physician 12:437–460PubMedCrossRef
12.
go back to reference Dillmann U, Nilges P, Saile H, Gerbershagen HU (1994) Assessing disability in chronic pain patients. Schmerz 8:100–110PubMedCrossRef Dillmann U, Nilges P, Saile H, Gerbershagen HU (1994) Assessing disability in chronic pain patients. Schmerz 8:100–110PubMedCrossRef
13.
go back to reference Dreyfuss P, Halbrook B, Pauza K, Joshi A, McLarty J, Bogduk N (2000) Efficacy and validity of radiofrequency neurotomy for chronic lumbar zygapophysial joint pain. Spine 25:1270–1277PubMedCrossRef Dreyfuss P, Halbrook B, Pauza K, Joshi A, McLarty J, Bogduk N (2000) Efficacy and validity of radiofrequency neurotomy for chronic lumbar zygapophysial joint pain. Spine 25:1270–1277PubMedCrossRef
14.
go back to reference Edwards SL, Slattery ML, Edwards AM, Sweeney C, Murtaugh MA, Palmer LE, Tom-Orme L (2009) Factors associated with response to a follow-up postal questionnaire in a cohort of American Indians. Prev Med 48:596–599PubMedCrossRef Edwards SL, Slattery ML, Edwards AM, Sweeney C, Murtaugh MA, Palmer LE, Tom-Orme L (2009) Factors associated with response to a follow-up postal questionnaire in a cohort of American Indians. Prev Med 48:596–599PubMedCrossRef
15.
go back to reference Gallagher J, Pettricione Di Vadi PL, Wedley JR, Hamann W, Ryan P, Chikanza I, Birkham B, Price R, Watson MS, Grahame R, Wood S (1994) Radiofrequency facet joint denervation in the treatment of low back pain: a prospective controlled double-blind study to assess it’s efficacy. Pain Clinic 7:193–198 Gallagher J, Pettricione Di Vadi PL, Wedley JR, Hamann W, Ryan P, Chikanza I, Birkham B, Price R, Watson MS, Grahame R, Wood S (1994) Radiofrequency facet joint denervation in the treatment of low back pain: a prospective controlled double-blind study to assess it’s efficacy. Pain Clinic 7:193–198
16.
go back to reference Geurts JW, van Wijk RM, Stolker RJ, Groen GJ (2001) Efficacy of radiofrequency procedures for the treatment of spinal pain: a systematic review of randomized clinical trials. Reg Anesth Pain Med 26:394–400PubMed Geurts JW, van Wijk RM, Stolker RJ, Groen GJ (2001) Efficacy of radiofrequency procedures for the treatment of spinal pain: a systematic review of randomized clinical trials. Reg Anesth Pain Med 26:394–400PubMed
17.
go back to reference Ghormly R (1933) Low back pain, with special reference to the articular facets, with presentation of an operative procedure. JAMA 101:1773–1777 Ghormly R (1933) Low back pain, with special reference to the articular facets, with presentation of an operative procedure. JAMA 101:1773–1777
18.
go back to reference Gofeld M, Jitendra J, Faclier G (2007) Radiofrequency denervation of the lumbar zygapophysial joints: 10-year prospective clinical audit. Pain Physician 10:291–300PubMed Gofeld M, Jitendra J, Faclier G (2007) Radiofrequency denervation of the lumbar zygapophysial joints: 10-year prospective clinical audit. Pain Physician 10:291–300PubMed
19.
go back to reference Green CR, de Rosayro M, Tait AR (2002) The role of cryoanalgesia for chronic thoracic pain: results of a long-term follow up. J Natl Med Assoc 94:716–720PubMed Green CR, de Rosayro M, Tait AR (2002) The role of cryoanalgesia for chronic thoracic pain: results of a long-term follow up. J Natl Med Assoc 94:716–720PubMed
20.
go back to reference Jones MJ, Murrin KR (1987) Intercostal block with cryotherapy. Ann R Coll Surg Engl 69:261–262PubMed Jones MJ, Murrin KR (1987) Intercostal block with cryotherapy. Ann R Coll Surg Engl 69:261–262PubMed
21.
go back to reference Kallakuri S, Singh A, Chen C, Cavanaugh JM (2004) Demonstration of substance P, calcitonin gene-related peptide, and protein gene product 9.5 containing nerve fibers in human cervical facet joint capsules. Spine 29:1182–1186PubMedCrossRef Kallakuri S, Singh A, Chen C, Cavanaugh JM (2004) Demonstration of substance P, calcitonin gene-related peptide, and protein gene product 9.5 containing nerve fibers in human cervical facet joint capsules. Spine 29:1182–1186PubMedCrossRef
22.
go back to reference Kornick C, Kramarich SS, Lamer TJ, Todd Sitzman B (2004) Complications of lumbar facet radiofrequency denervation. Spine (Phila Pa 1976) 29:1352-1354 Kornick C, Kramarich SS, Lamer TJ, Todd Sitzman B (2004) Complications of lumbar facet radiofrequency denervation. Spine (Phila Pa 1976) 29:1352-1354
23.
go back to reference Leclaire R, Fortin L, Lambert R, Bergeron YM, Rossignol M (2001) Radiofrequency facet joint denervation in the treatment of low back pain: a placebo-controlled clinical trial to assess efficacy. Spine 26:1411-1416; discussion 1417 Leclaire R, Fortin L, Lambert R, Bergeron YM, Rossignol M (2001) Radiofrequency facet joint denervation in the treatment of low back pain: a placebo-controlled clinical trial to assess efficacy. Spine 26:1411-1416; discussion 1417
24.
go back to reference Lu Y, Chen C, Kallakuri S, Patwardhan A, Cavanaugh JM (2005) Development of an in vivo method to investigate biomechanical and neurophysiological properties of spine facet joint capsules. Eur Spine J 14:565–572PubMedCrossRef Lu Y, Chen C, Kallakuri S, Patwardhan A, Cavanaugh JM (2005) Development of an in vivo method to investigate biomechanical and neurophysiological properties of spine facet joint capsules. Eur Spine J 14:565–572PubMedCrossRef
25.
go back to reference Manchikanti L, Boswell MV, Singh V, Pampati V, Damron KS, Beyer CD (2004) Prevalence of facet joint pain in chronic spinal pain of cervical, thoracic, and lumbar regions. BMC Musculoskelet Disord 5:15PubMedCrossRef Manchikanti L, Boswell MV, Singh V, Pampati V, Damron KS, Beyer CD (2004) Prevalence of facet joint pain in chronic spinal pain of cervical, thoracic, and lumbar regions. BMC Musculoskelet Disord 5:15PubMedCrossRef
26.
go back to reference Manchikanti L, Cash KA, Pampati V, Fellows B (2008) Influence of psychological variables on the diagnosis of facet joint involvement in chronic spinal pain. Pain Physician 11:145–160PubMed Manchikanti L, Cash KA, Pampati V, Fellows B (2008) Influence of psychological variables on the diagnosis of facet joint involvement in chronic spinal pain. Pain Physician 11:145–160PubMed
27.
go back to reference Manchikanti L, Pampati V, Fellows B, Bakhit CE (2000) The diagnostic validity and therapeutic value of lumbar facet joint nerve blocks with or without adjuvant agents. Curr Rev Pain 4:337–344PubMed Manchikanti L, Pampati V, Fellows B, Bakhit CE (2000) The diagnostic validity and therapeutic value of lumbar facet joint nerve blocks with or without adjuvant agents. Curr Rev Pain 4:337–344PubMed
28.
go back to reference Mattmüller R (2002) Radiofrequenzläsion und Kryoläsion. In: Hankemeier U, Hildebrandt J (eds) Neurodestruktive Verfahren in der Schmerztherapie. Springer, Berlin Heidelberg New York, pp 19–32 Mattmüller R (2002) Radiofrequenzläsion und Kryoläsion. In: Hankemeier U, Hildebrandt J (eds) Neurodestruktive Verfahren in der Schmerztherapie. Springer, Berlin Heidelberg New York, pp 19–32
29.
go back to reference Mayer TG, Gatchel RJ, Keeley J, McGeary D, Dersh J, Anagnostis C (2004) A randomized clinical trial of treatment for lumbar segmental rigidity. Spine 29:2199-2205; discussion 2206 Mayer TG, Gatchel RJ, Keeley J, McGeary D, Dersh J, Anagnostis C (2004) A randomized clinical trial of treatment for lumbar segmental rigidity. Spine 29:2199-2205; discussion 2206
30.
go back to reference Mayer TG, Robinson R, Pegues P, Kohles S, Gatchel RJ (2000) Lumbar segmental rigidity: can its identification with facet injections and stretching exercises be useful? Arch Phys Med Rehabil 81:1143–1150PubMedCrossRef Mayer TG, Robinson R, Pegues P, Kohles S, Gatchel RJ (2000) Lumbar segmental rigidity: can its identification with facet injections and stretching exercises be useful? Arch Phys Med Rehabil 81:1143–1150PubMedCrossRef
31.
go back to reference McLain RF, Pickar JG (1998) Mechanoreceptor endings in human thoracic and lumbar facet joints. Spine 23:168–173PubMedCrossRef McLain RF, Pickar JG (1998) Mechanoreceptor endings in human thoracic and lumbar facet joints. Spine 23:168–173PubMedCrossRef
32.
go back to reference Nagel B, Gerbershagen HU, Lindena G, Pfingsten M (2002) Development and evaluation of the multidimensional German pain questionnaire. Schmerz 16:263–270PubMedCrossRef Nagel B, Gerbershagen HU, Lindena G, Pfingsten M (2002) Development and evaluation of the multidimensional German pain questionnaire. Schmerz 16:263–270PubMedCrossRef
33.
go back to reference Nath S, Nath CA, Pettersson K (2008) Percutaneous lumbar zygapophysial (Facet) joint neurotomy using radiofrequency current, in the management of chronic low back pain: a randomized double-blind trial. Spine (Phila Pa 1976) 33:1291-1297; discussion 1298 Nath S, Nath CA, Pettersson K (2008) Percutaneous lumbar zygapophysial (Facet) joint neurotomy using radiofrequency current, in the management of chronic low back pain: a randomized double-blind trial. Spine (Phila Pa 1976) 33:1291-1297; discussion 1298
34.
go back to reference Niemisto L, Kalso E, Malmivaara A, Seitsalo S, Hurri H (2003) Radiofrequency denervation for neck and back pain: a systematic review within the framework of the cochrane collaboration back review group. Spine 28:1877–1888PubMedCrossRef Niemisto L, Kalso E, Malmivaara A, Seitsalo S, Hurri H (2003) Radiofrequency denervation for neck and back pain: a systematic review within the framework of the cochrane collaboration back review group. Spine 28:1877–1888PubMedCrossRef
35.
go back to reference Ohtori S, Takahashi K, Chiba T, Yamagata M, Sameda H, Moriya H (2003) Calcitonin gene-related peptide immunoreactive neurons with dichotomizing axons projecting to the lumbar muscle and knee in rats. Eur Spine J 12:576–580PubMedCrossRef Ohtori S, Takahashi K, Chiba T, Yamagata M, Sameda H, Moriya H (2003) Calcitonin gene-related peptide immunoreactive neurons with dichotomizing axons projecting to the lumbar muscle and knee in rats. Eur Spine J 12:576–580PubMedCrossRef
36.
go back to reference Oudenhoven RC (1982) Lumbar monoradiculopathy due to unilateral facet hypertrophy. Neurosurgery 11:726–727PubMedCrossRef Oudenhoven RC (1982) Lumbar monoradiculopathy due to unilateral facet hypertrophy. Neurosurgery 11:726–727PubMedCrossRef
37.
go back to reference Robinson SR, Purdie GL (2000) Reducing post-tonsillectomy pain with cryoanalgesia: a randomized controlled trial. Laryngoscope 110:1128–1131PubMedCrossRef Robinson SR, Purdie GL (2000) Reducing post-tonsillectomy pain with cryoanalgesia: a randomized controlled trial. Laryngoscope 110:1128–1131PubMedCrossRef
38.
go back to reference Schulte TL, Pietila TA, Heidenreich J, Brock M, Stendel R (2006) Injection therapy of lumbar facet syndrome: a prospective study. Acta Neurochir (Wien) 148:1165-1172; discussion 1172 Schulte TL, Pietila TA, Heidenreich J, Brock M, Stendel R (2006) Injection therapy of lumbar facet syndrome: a prospective study. Acta Neurochir (Wien) 148:1165-1172; discussion 1172
39.
go back to reference Schwarzer AC, Aprill CN, Derby R, Fortin J, Kine G, Bogduk N (1994) The false-positive rate of uncontrolled diagnostic blocks of the lumbar zygapophysial joints. Pain 58:195–200PubMedCrossRef Schwarzer AC, Aprill CN, Derby R, Fortin J, Kine G, Bogduk N (1994) The false-positive rate of uncontrolled diagnostic blocks of the lumbar zygapophysial joints. Pain 58:195–200PubMedCrossRef
40.
go back to reference Staender M, Maerz U, Tonn JC, Steude U (2005) Computerized tomography-guided kryorhizotomy in 76 patients with lumbar facet joint syndrome. J Neurosurg Spine 3:444–449PubMedCrossRef Staender M, Maerz U, Tonn JC, Steude U (2005) Computerized tomography-guided kryorhizotomy in 76 patients with lumbar facet joint syndrome. J Neurosurg Spine 3:444–449PubMedCrossRef
41.
go back to reference Trescot AM (2003) Cryoanalgesia in interventional pain management. Pain Physician 6:345–360PubMed Trescot AM (2003) Cryoanalgesia in interventional pain management. Pain Physician 6:345–360PubMed
42.
go back to reference van Kleef M, Barendse GA, Kessels A, Voets HM, Weber WE, de Lange S (1999) Randomized trial of radiofrequency lumbar facet denervation for chronic low back pain. Spine 24:1937–1942PubMedCrossRef van Kleef M, Barendse GA, Kessels A, Voets HM, Weber WE, de Lange S (1999) Randomized trial of radiofrequency lumbar facet denervation for chronic low back pain. Spine 24:1937–1942PubMedCrossRef
43.
go back to reference van Wijk RM, Geurts JW, Lousberg R, Wynne HJ, Hammink E, Knape JT, Groen GJ (2008) Psychological predictors of substantial pain reduction after minimally invasive radiofrequency and injection treatments for chronic low back pain. Pain Med 9:212–221PubMedCrossRef van Wijk RM, Geurts JW, Lousberg R, Wynne HJ, Hammink E, Knape JT, Groen GJ (2008) Psychological predictors of substantial pain reduction after minimally invasive radiofrequency and injection treatments for chronic low back pain. Pain Med 9:212–221PubMedCrossRef
44.
go back to reference van Wijk RM, Geurts JW, Wynne HJ, Hammink E, Buskens E, Lousberg R, Knape JT, Groen GJ (2005) Radiofrequency denervation of lumbar facet joints in the treatment of chronic low back pain: a randomized, double-blind, sham lesion-controlled trial. Clin J Pain 21:335–344PubMedCrossRef van Wijk RM, Geurts JW, Wynne HJ, Hammink E, Buskens E, Lousberg R, Knape JT, Groen GJ (2005) Radiofrequency denervation of lumbar facet joints in the treatment of chronic low back pain: a randomized, double-blind, sham lesion-controlled trial. Clin J Pain 21:335–344PubMedCrossRef
45.
go back to reference Wilde GP, Szypryt EP, Mulholland RC (1988) Unilateral lumbar facet joint hypertrophy causing nerve root irritation. Ann R Coll Surg Engl 70:307–310PubMed Wilde GP, Szypryt EP, Mulholland RC (1988) Unilateral lumbar facet joint hypertrophy causing nerve root irritation. Ann R Coll Surg Engl 70:307–310PubMed
Metadata
Title
Cryoneurolysis for zygapophyseal joint pain: a retrospective analysis of 117 interventions
Authors
Tilman Wolter
M. Deininger
U. Hubbe
M. Mohadjer
S. Knoeller
Publication date
01-05-2011
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 5/2011
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-011-0966-9

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