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Open Access 01-12-2023 | COVID-19 | Research

Severity of oxidative stress as a hallmark in COVID-19 patients

Authors: Alireza Bastin, Fatemeh Abbasi, Narges Roustaei, Jahangir Abdesheikhi, Hossein Karami, Mohammad Gholamnezhad, Mahdieh Eftekhari, Amirhossein Doustimotlagh

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

Introduction

Understanding the mechanisms and identifying effective treatments for the COVID-19 outbreak are imperative. Therefore, this study aimed to assess the antioxidant status and oxidative stress parameters as potential pivotal mechanisms in asymptomatic, non-severe, and severe COVID-19 patients.

Methods

This study is a case–control study that was performed on patients referred to the Persian Gulf Martyrs Hospital of Bushehr University of Medical Sciences, Bushehr, Iran, from May 2021 to September 2021. A total of 600 COVID-19 patients (non-severe and severe group) and 150 healthy volunteers of the same age and sex were selected during the same period. On the first day of hospitalization, 10 ml of venous blood was taken from subjects. Then, hematological, biochemical, serological, antioxidant and oxidative stress parameters were determined.

Results

Our results indicated that ESR, CRP, AST, ALT, and LDH significantly augmented in the severe group as compared to the non-severe and normal groups (P ≤ 0.05). It was observed that the levels of FRAP, G6PD activity, and SOD activity significantly reduced in the non-severe patients in comparison with the severe and normal groups (P ≤ 0.05). We found that MDA content and NO metabolite markedly increased in severe patients as compared to the non-severe group.

Conclusions

Taken together, it seems that the balance between antioxidants and oxidants was disturbed in COVID-19 patients in favor of oxidant markers. In addition, this situation caused more aggravation in severe patients as compared to the non-severe group.

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Title: Severity of oxidative stress as a hallmark in COVID-19 patients
Authors: Alireza Bastin
Fatemeh Abbasi
Narges Roustaei
Jahangir Abdesheikhi
Hossein Karami
Mohammad Gholamnezhad
Mahdieh Eftekhari
Amirhossein Doustimotlagh
Publication date: 01-12-2023
Publisher: BioMed Central
Keyword: COVID-19
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-023-01401-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Severity of oxidative stress as a hallmark in COVID-19 patients

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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