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Open Access 01-12-2020 | Coronavirus | Review

2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies

Authors: Jun She, Jinjun Jiang, Ling Ye, Lijuan Hu, Chunxue Bai, Yuanlin Song

Published in: Clinical and Translational Medicine | Issue 1/2020

Abstract

An ongoing outbreak of 2019-nCoV pneumonia was first identified in Wuhan, Hubei province, China at the end of 2019. With the spread of the new coronavirus accelerating, person-to-person transmission in family homes or hospitals, and intercity spread of 2019-nCoV occurred. At least 40,261 cases confirmed, 23,589 cases suspected, 909 cases death and 3444 cases cured in China and worldwide 24 countries confirmed 383 cases being diagnosed, 1 case death in February 10th, 2020. At present, the mortality of 2019-nCoV in China is 2.3%, compared with 9.6% of SARS and 34.4% of MERS reported by WHO. It seems the new virus is not as fatal as many people thought. Chinese authorities improved surveillance network, made the laboratory be able to recognize the outbreak within a few weeks and announced the virus genome that provide efficient epidemiological control. More comprehensive information is required to understand 2019-nCoV feature, the epidemiology of origin and spreading, and the clinical phenomina. According to the current status, blocking transmission, isolation, protection, and alternative medication are the urgent management strategies against 2019-nCoV.

Zhu N, Zhang DY, Wang WL et al (2020) A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. https://doi.org/10.1056/nejmoa2001017 CrossRefPubMedPubMedCentral

Huang CL, Wang YM, Li XW et al (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. https://doi.org/10.1016/s0140-6736(20)30183-5 CrossRefPubMedPubMedCentral

New features of novel coronavirus (2019-nCoV) pneumonia. https://new.qq.com/omn/20200128/20200128A07H4S00.html. Accessed 30 Jan 2020

Novel coronavirus (2019-nCoV) situation Report-7 http://www.who.int/docs/default-source/coronavirus/situation-report/20200127-sitrep-7-2019–ncov.pdf?sfvrsn=98ef79f5_2. Accessed 27 Jan 2020)

Weiss SR, Leibowitz JL (2011) Coronavirus pathogenesis. Adv Virus Res 81:85164

Su S, Wong G, Shi W et al (2016) Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol 24:490–502CrossRefPubMedPubMedCentral

Cui J, Li F, Shi ZL (2019) Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol 17:181–192CrossRefPubMed

Wong G, Liu W, Liu Y, Zhou B, Bi Y, Gao GF (2015) MERS, SARS, and Ebola: the role of super-spreaders in infectious disease. Cell Host Microbe 18:398–401CrossRefPubMedPubMedCentral

Perlman S (2020) Another decade, another coronavirus. N Engl J Med. https://doi.org/10.1056/nejme2001126 CrossRefPubMedPubMedCentral

10.

Lu RJ, Zhao X, Li J et al (2020) Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. https://doi.org/10.1016/s0140-6736(20)30251-8 CrossRefPubMedPubMedCentral

11.

Zhou P, Yang XL, Wang XG et al (2020) Discovery of a novel coronavirus associated with the recent pneumonia outbreak in 2 humans and its potential bat origin. BioRxiv. https://doi.org/10.1101/2020.01.22.914952 CrossRefPubMedPubMedCentral

12.

Cohen J. Wuhan seafood market may not be source of novel virus spreading globally.https://www.sciencemag.org/news/2020/01/wuhan-seafood-market-may-not-be-source-novel-virus-spreading-globally. Accessed 30 Jan 2020

13.

Li Q, Guan XH, Wu P et al (2020) Early transmission dynamics in Wuhan, China, of novel coronavirus infected pneumonia. N Engl J Med. https://doi.org/10.1056/nejmoa2001316 CrossRefPubMedPubMedCentral

14.

Phan LT, Nguyen TV, Luong QC et al (2020) Importation and human-to-human transmission of a novel coronavirus in Vietnam. N Engl J Med. https://doi.org/10.1056/nejmoa2001272 CrossRefPubMedPubMedCentral

15.

Xiong P, Zeng X, Song MS et al (2008) Lack of association between HLA-A, -B and -DRB1 alleles and the development of SARS: a cohort of 95 SARS-recovered individuals in a population of Guangdong, southern China. Int J Immunogenet 35:69–74. https://doi.org/10.1111/j.1744-313X.2007.00741.x CrossRefPubMedPubMedCentral

16.

Vincent JM, Marion K, van Doremalen N et al (2020) A novel coronavirus emerging in China—key questions for impact assessment. N Engl J Med. https://doi.org/10.1056/nejmp2000929 CrossRefPubMed

17.

Chen NS, Zhou M, Dong X et al (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. https://doi.org/10.1016/s0140-6736(20)30211-7 CrossRefPubMedPubMedCentral

18.

WHO statement regarding cluster of pneumonia cases in Wuhan, China. https://www.who.int/china/news/detail/09-01-2020-who-statement-regarding-cluster-of-pneumonia-cases-in-wuhan-china. Accessed 27 Jan 2020

19.

Yuan JS, Yun HM, Lan W et al (2005) A climatologic investigation of the SARS-CoV outbreak in Beijing. China Am J Infect Control 34:234–236. https://doi.org/10.1016/j.ajic.2005.12.006 CrossRef

20.

National Health Commission of the People’s Republic of China. Diagnosis and treatment of new coronavirus pneumonia (version 5) http://www.nhc.gov.cn/. Accessed 30 Jan 2020

21.

Chan Jasper FW, Yuan SF, Kok KH et al (2020) A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. https://doi.org/10.1016/s0140-6736(20)30154-9 CrossRefPubMedPubMedCentral

22.

Memish ZA, Al-Tawfiq JA, Makhdoom HQ et al (2014) Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome. J Infect Dis 210:1590–1594CrossRefPubMed

23.

Hung IF, Cheng VC, Wu AK et al (2004) Viral loads in clinical specimens and SARS manifestations. Emerg Infect Dis 10:1550–1557CrossRefPubMedPubMedCentral

24.

Holshue ML, DeBolt C, Lindquis S et al (2020) First case of 2019 novel coronavirus in the United States. N Engl J Med. https://doi.org/10.1056/nejmoa2001191 CrossRefPubMedPubMedCentral

25.

The Washington Post https://www.washingtonpost.com/health/chinese-leader-warns-of-accelerating-spread-of-deadly-coronavirus/2020/01/25/6409bc78-3f8c-11ea-baca-eb7ace0a3455_story.html. Accessed 25 Jan 2020

26.

Wang C, Horby PE, Hayden FG et al (2020) A novel coronavirus outbreak of global health concern. Lancet. https://doi.org/10.1016/s0140-6736(20)30182-9 CrossRefPubMedPubMedCentral

27.

Hui DS, Azhar EI, Kim YJ, Memish ZA, Oh MD, Zumla A (2018) Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission. Lancet Infect Dis 18:e217–e227CrossRefPubMedPubMedCentral

28.

Peiris JS, Guan Y, Yuen KY (2004) Severe acute respiratory syndrome. Nat Med 10(Suppl):S88–S97CrossRefPubMedPubMedCentral

29.

Carlos WG, Cruz CSD, Cao B et al (2020) Novel Wuhan (2019-nCoV) Coronavirus. Am J Respir Crit Care Med. https://doi.org/10.1164/rccm.2014p7 CrossRefPubMed

30.

Interim infection prevention and control recommendations for patients with known or patients under investigation for 2019 novel coronavirus (2019-nCoV) in a healthcare setting. https://www.cdc.gov/coronavirus/2019-nCoV/hcp/infection-control.html. Accessed 30 Jan 2020

31.

Chu CM (2004) Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings. Thorax 59:252–256CrossRefPubMedPubMedCentral

32.

Arabi YM, Alothman A, Balkhy HH et al (2018) Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial. Trials 19:81CrossRefPubMedPubMedCentral

33.

Tian XL, Li C, Huang AL et al (2019) A potent binding of 2019-nCoV spike protein by a SARS-CoV specific human monoclonal antibody. bioRxiv. https://doi.org/10.1101/2020.01.28.923011v1 CrossRef

34.

Arabi YM, Mandourah Y, Al-Hameed F et al (2018) Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome. Am J Respir Crit Care Med 197:757–767CrossRefPubMed

35.

WHO. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. Jan 11, 2020. https://www.who.int/internal-publications-detail/clinicalmanagement-of-severe-acute-respiratory-infection-when-novelcoronavirus-(ncov)-infection-is-suspected. Accessed 30 Jan 2020

36.

LianhuaQingwenis is recommended for new coronavirus treatment.http://www.p5w.net/stock/news/gsxw/202001/t20200128_2373523.htm. Accessed 30 Jan 2020

37.

Ma QH, Huang WB, Zhao J, Yang ZF (2020) Liu Shen Wan inhibits influenza a virus and excessive virus-induced inflammatory response via suppression of TLR4/NF-KB signaling pathway in vitro and in vivo. J Ethnopharmacol. https://doi.org/10.1016/j.jep.2020.112584 CrossRefPubMedPubMedCentral

Title: 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies
Authors: Jun She
Jinjun Jiang
Ling Ye
Lijuan Hu
Chunxue Bai
Yuanlin Song
Publication date: 01-12-2020
Publisher: Springer Berlin Heidelberg
Keywords: Coronavirus
Severe Acute Respiratory Syndrome Coronavirus
Middle Eastern Respiratory Syndrome
Pneumonia
Published in: Clinical and Translational Medicine / Issue 1/2020
Electronic ISSN: 2001-1326
DOI: https://doi.org/10.1186/s40169-020-00271-z

At a glance: The STEP trials

Springer Medicine

2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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