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Journal of Thrombosis and Thrombolysis
Published in: Journal of Thrombosis and Thrombolysis 3/2021

01-04-2021 | COVID-19

Impact of COVID-19 on monitoring of therapeutic unfractionated heparin

Authors: Sarah K. Adie, Nicholas Farina

Published in: Journal of Thrombosis and Thrombolysis | Issue 3/2021

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Excerpt

  • Anti-Xa and aPTT are prone to monitoring inaccuracies in patients with COVID-19 and severe illness.
  • Unexpected thrombosis or bleeding that does not correlate with anti-Xa or aPTT levels may indicate level inaccuracies
  • More research is needed on the monitoring assay to optimize UFH dose titration in COVID-19 patients
…
Literature
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Bikdeli B, Madhavan MV, Jimenez D et al (2020) COVID-19 and thrombotic and thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up. J Am Coll Cardiol. 75:2950–2973CrossRef
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Tang N, Li D, Wang X, Sun Z (2020) Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 18:844–847CrossRef
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Tang N, Bai H, Chen X, Gong J, Li D, Sun Z (2020) Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost 18:1094–1099CrossRef
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Artim-Esen B, Pericleous C, Mackie I et al (2015) Anti-factor Xa antibodies in patients with antiphospholipid syndrome and their effects upon coagulation assays. Arthritis Res Ther 1:47CrossRef
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Zhang Y, Xiao M, Zhang S et al (2020) Coagulopathy and antiphospholipid antibodies in patients with COVID-19. N Engl J Med 382:e38CrossRef
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Vandiver JW, Vondracek TG (2012) Antifactor Xa levels versus activated partial thromboplastin time for monitoring unfractionated heparin. Pharmacotherapy 32(6):546–558CrossRef
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Spiezia L, Boscolo A, Poletta F et al (2020) COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure. Thromb Haemost. 120:998CrossRef
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Borges AH, O'Connor JL, Phillips AN et al (2014) Factors associated with D-dimer levels in HIV-infected individuals. PLoS ONE 9:e90978CrossRef
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Ramacciotti E, Agati LB, Aguiar VCR et al (2019) Zika and Chikungunya virus and risk for venous thromboembolism. Clin Appl Thromb Hemost 25:1076029618821184PubMedPubMedCentral
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Smither SJ, O'Brien LM, Eastaugh L et al (2019) Haemostatic changes in five patients infected with Ebola virus. Viruses 11:647CrossRef
Metadata
Title
Impact of COVID-19 on monitoring of therapeutic unfractionated heparin
Authors
Sarah K. Adie
Nicholas Farina
Publication date
01-04-2021
Publisher
Springer US
Keywords
COVID-19
Heparin
Published in
Journal of Thrombosis and Thrombolysis / Issue 3/2021
Print ISSN: 0929-5305
Electronic ISSN: 1573-742X
DOI
https://doi.org/10.1007/s11239-020-02250-0

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