Skip to main content
Top
Published in: BMC Medicine 1/2022

01-12-2022 | COVID-19 | Research article

Comparative assessment of methods for short-term forecasts of COVID-19 hospital admissions in England at the local level

Authors: Sophie Meakin, Sam Abbott, Nikos Bosse, James Munday, Hugo Gruson, Joel Hellewell, Katharine Sherratt, Sebastian Funk, CMMID COVID-19 Working Group

Published in: BMC Medicine | Issue 1/2022

Login to get access

Abstract

Background

Forecasting healthcare demand is essential in epidemic settings, both to inform situational awareness and facilitate resource planning. Ideally, forecasts should be robust across time and locations. During the COVID-19 pandemic in England, it is an ongoing concern that demand for hospital care for COVID-19 patients in England will exceed available resources.

Methods

We made weekly forecasts of daily COVID-19 hospital admissions for National Health Service (NHS) Trusts in England between August 2020 and April 2021 using three disease-agnostic forecasting models: a mean ensemble of autoregressive time series models, a linear regression model with 7-day-lagged local cases as a predictor, and a scaled convolution of local cases and a delay distribution. We compared their point and probabilistic accuracy to a mean-ensemble of them all and to a simple baseline model of no change from the last day of admissions. We measured predictive performance using the weighted interval score (WIS) and considered how this changed in different scenarios (the length of the predictive horizon, the date on which the forecast was made, and by location), as well as how much admissions forecasts improved when future cases were known.

Results

All models outperformed the baseline in the majority of scenarios. Forecasting accuracy varied by forecast date and location, depending on the trajectory of the outbreak, and all individual models had instances where they were the top- or bottom-ranked model. Forecasts produced by the mean-ensemble were both the most accurate and most consistently accurate forecasts amongst all the models considered. Forecasting accuracy was improved when using future observed, rather than forecast, cases, especially at longer forecast horizons.

Conclusions

Assuming no change in current admissions is rarely better than including at least a trend. Using confirmed COVID-19 cases as a predictor can improve admissions forecasts in some scenarios, but this is variable and depends on the ability to make consistently good case forecasts. However, ensemble forecasts can make forecasts that make consistently more accurate forecasts across time and locations. Given minimal requirements on data and computation, our admissions forecasting ensemble could be used to anticipate healthcare needs in future epidemic or pandemic settings.
Appendix
Available only for authorised users
Literature
1.
go back to reference Papst I, Li M, Champredon D, Bolker BM, Dushoff J, Earn DJ. Age-dependence of healthcare interventions for COVID-19 in Ontario, Canada. BMC Public Health. 2021;21:706.CrossRef Papst I, Li M, Champredon D, Bolker BM, Dushoff J, Earn DJ. Age-dependence of healthcare interventions for COVID-19 in Ontario, Canada. BMC Public Health. 2021;21:706.CrossRef
2.
go back to reference Verity R, Okell LC, Dorigatti I, Winskill P, Whittaker C, Imai N, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 2020;20:669–77.CrossRef Verity R, Okell LC, Dorigatti I, Winskill P, Whittaker C, Imai N, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 2020;20:669–77.CrossRef
3.
go back to reference Wilde H, Mellan T, Hawryluk I, Dennis JM, Denaxas S, Pagel C, et al. The association between mechanical ventilator compatible bed occupancy and mortality risk in intensive care patients with COVID-19: a national retrospective cohort study. BMC Med. 2021;19:213.CrossRef Wilde H, Mellan T, Hawryluk I, Dennis JM, Denaxas S, Pagel C, et al. The association between mechanical ventilator compatible bed occupancy and mortality risk in intensive care patients with COVID-19: a national retrospective cohort study. BMC Med. 2021;19:213.CrossRef
4.
go back to reference Carr A, Smith JA, Camaradou J, Prieto-Alhambra D. Growing backlog of planned surgery due to covid-19. BMJ. 2021;372:n339.CrossRef Carr A, Smith JA, Camaradou J, Prieto-Alhambra D. Growing backlog of planned surgery due to covid-19. BMJ. 2021;372:n339.CrossRef
6.
go back to reference Andronico A, Dorléans F, Fergé J-L, Salje H, Ghawché F, Signate A, et al. Real-Time Assessment of Health-Care Requirements During the Zika Virus Epidemic in Martinique. Am J Epidemiol. 2017;186:1194–203.CrossRef Andronico A, Dorléans F, Fergé J-L, Salje H, Ghawché F, Signate A, et al. Real-Time Assessment of Health-Care Requirements During the Zika Virus Epidemic in Martinique. Am J Epidemiol. 2017;186:1194–203.CrossRef
7.
go back to reference Finger F, Funk S, White K, Siddiqui MR, Edmunds WJ, Kucharski AJ. Real-time analysis of the diphtheria outbreak in forcibly displaced Myanmar nationals in Bangladesh. BMC Med. 2019;17:58.CrossRef Finger F, Funk S, White K, Siddiqui MR, Edmunds WJ, Kucharski AJ. Real-time analysis of the diphtheria outbreak in forcibly displaced Myanmar nationals in Bangladesh. BMC Med. 2019;17:58.CrossRef
10.
go back to reference Castro LA, Shelley CD, Osthus D, Michaud I, Mitchell J, Manore CA, et al. How New Mexico Leveraged a COVID-19 Case Forecasting Model to Preemptively Address the Health Care Needs of the State: Quantitative Analysis. JMIR Public Health Surveill. 2021;7:e27888.CrossRef Castro LA, Shelley CD, Osthus D, Michaud I, Mitchell J, Manore CA, et al. How New Mexico Leveraged a COVID-19 Case Forecasting Model to Preemptively Address the Health Care Needs of the State: Quantitative Analysis. JMIR Public Health Surveill. 2021;7:e27888.CrossRef
11.
go back to reference Leclerc QJ, Fuller NM, Keogh RH, Diaz-Ordaz K, Sekula R, Semple MG, et al. Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC Health Serv Res. 2021;21:566.CrossRef Leclerc QJ, Fuller NM, Keogh RH, Diaz-Ordaz K, Sekula R, Semple MG, et al. Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC Health Serv Res. 2021;21:566.CrossRef
12.
go back to reference Verhagen MD, Brazel DM, Dowd JB, Kashnitsky I, Mills MC. Forecasting spatial, socioeconomic and demographic variation in COVID-19 health care demand in England and Wales. BMC Med. 2020;18:203.CrossRef Verhagen MD, Brazel DM, Dowd JB, Kashnitsky I, Mills MC. Forecasting spatial, socioeconomic and demographic variation in COVID-19 health care demand in England and Wales. BMC Med. 2020;18:203.CrossRef
13.
go back to reference Pagel C, Banks V, Pope C, Whitmore P, Brown K, Goldman A, et al. Development, implementation and evaluation of a tool for forecasting short term demand for beds in an intensive care unit. Oper Res Health Care. 2017;15:19–31.CrossRef Pagel C, Banks V, Pope C, Whitmore P, Brown K, Goldman A, et al. Development, implementation and evaluation of a tool for forecasting short term demand for beds in an intensive care unit. Oper Res Health Care. 2017;15:19–31.CrossRef
15.
go back to reference Alaa A, Qian Z, Rashbass J, Benger J, van der Schaar M. Retrospective cohort study of admission timing and mortality following COVID-19 infection in England. BMJ Open. 2020;10:e042712.CrossRef Alaa A, Qian Z, Rashbass J, Benger J, van der Schaar M. Retrospective cohort study of admission timing and mortality following COVID-19 infection in England. BMJ Open. 2020;10:e042712.CrossRef
16.
go back to reference Faes C, Abrams S, Van Beckhoven D, Meyfroidt G, Vlieghe E, Hens N, et al. Time between Symptom Onset, Hospitalisation and Recovery or Death: Statistical Analysis of Belgian COVID-19 Patients. Int J Environ Res Public Health. 2020;17. https://doi.org/10.3390/ijerph17207560. Faes C, Abrams S, Van Beckhoven D, Meyfroidt G, Vlieghe E, Hens N, et al. Time between Symptom Onset, Hospitalisation and Recovery or Death: Statistical Analysis of Belgian COVID-19 Patients. Int J Environ Res Public Health. 2020;17. https://​doi.​org/​10.​3390/​ijerph17207560.
17.
go back to reference Hyndman RJ, Athanasopoulos G. Forecasting: principles and practice. 2018. OTexts. Hyndman RJ, Athanasopoulos G. Forecasting: principles and practice. 2018. OTexts.
18.
go back to reference Ray EL, Reich NG. Prediction of infectious disease epidemics via weighted density ensembles. PLoS Comput Biol. 2018;14:e1005910.CrossRef Ray EL, Reich NG. Prediction of infectious disease epidemics via weighted density ensembles. PLoS Comput Biol. 2018;14:e1005910.CrossRef
19.
go back to reference Vollmer MAC, Glampson B, Mellan T, Mishra S, Mercuri L, Costello C, et al. A unified machine learning approach to time series forecasting applied to demand at emergency departments. BMC Emerg Med. 2021;21:9.CrossRef Vollmer MAC, Glampson B, Mellan T, Mishra S, Mercuri L, Costello C, et al. A unified machine learning approach to time series forecasting applied to demand at emergency departments. BMC Emerg Med. 2021;21:9.CrossRef
23.
go back to reference Bracher J, Wolffram D, Deuschel J, Görgen K, Ketterer JL, Ullrich A, et al. A pre-registered short-term forecasting study of COVID-19 in Germany and Poland during the second wave. Nat Commun. 2021;12:5173.CrossRef Bracher J, Wolffram D, Deuschel J, Görgen K, Ketterer JL, Ullrich A, et al. A pre-registered short-term forecasting study of COVID-19 in Germany and Poland during the second wave. Nat Commun. 2021;12:5173.CrossRef
24.
go back to reference Reich NG, Brooks LC, Fox SJ, Kandula S, McGowan CJ, Moore E, et al. A collaborative multiyear, multimodel assessment of seasonal influenza forecasting in the United States. Proc Natl Acad Sci U S A. 2019;116:3146–54.CrossRef Reich NG, Brooks LC, Fox SJ, Kandula S, McGowan CJ, Moore E, et al. A collaborative multiyear, multimodel assessment of seasonal influenza forecasting in the United States. Proc Natl Acad Sci U S A. 2019;116:3146–54.CrossRef
25.
go back to reference Viboud C, Sun K, Gaffey R, Ajelli M, Fumanelli L, Merler S, et al. The RAPIDD ebola forecasting challenge: Synthesis and lessons learnt. Epidemics. 2018;22:13–21.CrossRef Viboud C, Sun K, Gaffey R, Ajelli M, Fumanelli L, Merler S, et al. The RAPIDD ebola forecasting challenge: Synthesis and lessons learnt. Epidemics. 2018;22:13–21.CrossRef
31.
go back to reference Sorensen TA. A method of establishing groups of equal amplitude in plant sociology based on similarity of species content and its application to analyses of the vegetation on Danish commons. Biol Skar. 1948;5:1–34. Sorensen TA. A method of establishing groups of equal amplitude in plant sociology based on similarity of species content and its application to analyses of the vegetation on Danish commons. Biol Skar. 1948;5:1–34.
32.
go back to reference Abbott S, Hickson J, Ellis P, Badr HS, Allen J, Munday JD, et al. COVID-19: National and Subnational estimates for the United Kingdom. https://epiforecasts io/covid/posts/national/united-kingdom/. Accessed on 16 Oct 2020. Abbott S, Hickson J, Ellis P, Badr HS, Allen J, Munday JD, et al. COVID-19: National and Subnational estimates for the United Kingdom. https://​epiforecasts io/covid/posts/national/united-kingdom/.​ Accessed on 16 Oct 2020.
33.
go back to reference Hyndman RJ, Khandakar Y. Automatic Time Series Forecasting: The forecast Package for R. J Stat Softw. 2008;27:1–22.CrossRef Hyndman RJ, Khandakar Y. Automatic Time Series Forecasting: The forecast Package for R. J Stat Softw. 2008;27:1–22.CrossRef
37.
go back to reference Zivot E, Wang J. Modeling Financial Time Series with S-PLUS. 3rd ed. New York: Springer Science & Business Media; 2003.CrossRef Zivot E, Wang J. Modeling Financial Time Series with S-PLUS. 3rd ed. New York: Springer Science & Business Media; 2003.CrossRef
38.
go back to reference Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020;172:577–82.CrossRef Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020;172:577–82.CrossRef
40.
go back to reference Abbott S, Hellewell J, Thompson RN, Sherratt K, Gibbs HP, Bosse NI, et al. Estimating the time-varying reproduction number of SARS-CoV-2 using national and subnational case counts. Wellcome Open Res. 2020;5:112.CrossRef Abbott S, Hellewell J, Thompson RN, Sherratt K, Gibbs HP, Bosse NI, et al. Estimating the time-varying reproduction number of SARS-CoV-2 using national and subnational case counts. Wellcome Open Res. 2020;5:112.CrossRef
42.
go back to reference Gneiting T, Raftery AE. Strictly Proper Scoring Rules, Prediction, and Estimation. J Am Stat Assoc. 2007;102:359–78.CrossRef Gneiting T, Raftery AE. Strictly Proper Scoring Rules, Prediction, and Estimation. J Am Stat Assoc. 2007;102:359–78.CrossRef
43.
go back to reference Bracher J, Ray EL, Gneiting T, Reich NG. Evaluating epidemic forecasts in an interval format. PLoS Comput Biol. 2021;17:e1008618.CrossRef Bracher J, Ray EL, Gneiting T, Reich NG. Evaluating epidemic forecasts in an interval format. PLoS Comput Biol. 2021;17:e1008618.CrossRef
48.
go back to reference Reich NG, CJ MG, Yamana TK, Tushar A, Ray EL, Osthus D, et al. Accuracy of real-time multi-model ensemble forecasts for seasonal influenza in the U.S. PLoS Comput Biol. 2019;15:e1007486.CrossRef Reich NG, CJ MG, Yamana TK, Tushar A, Ray EL, Osthus D, et al. Accuracy of real-time multi-model ensemble forecasts for seasonal influenza in the U.S. PLoS Comput Biol. 2019;15:e1007486.CrossRef
49.
go back to reference Fabbri D, Robone S. The geography of hospital admission in a national health service with patient choice. Health Econ. 2010;19:1029–47.CrossRef Fabbri D, Robone S. The geography of hospital admission in a national health service with patient choice. Health Econ. 2010;19:1029–47.CrossRef
50.
go back to reference Balia S, Brau R, Marrocu E. What drives patient mobility across Italian regions? Evidence from hospital discharge data. Dev Health Econ Public Policy. 2014;12:133–54.PubMed Balia S, Brau R, Marrocu E. What drives patient mobility across Italian regions? Evidence from hospital discharge data. Dev Health Econ Public Policy. 2014;12:133–54.PubMed
Metadata
Title
Comparative assessment of methods for short-term forecasts of COVID-19 hospital admissions in England at the local level
Authors
Sophie Meakin
Sam Abbott
Nikos Bosse
James Munday
Hugo Gruson
Joel Hellewell
Katharine Sherratt
Sebastian Funk
CMMID COVID-19 Working Group
Publication date
01-12-2022
Publisher
BioMed Central
Keyword
COVID-19
Published in
BMC Medicine / Issue 1/2022
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-022-02271-x

Other articles of this Issue 1/2022

BMC Medicine 1/2022 Go to the issue