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Lung
Published in: Lung 1/2010

01-01-2010

Cough: The Emerging Role of the TRPA1 Channel

Authors: Pierangelo Geppetti, Riccardo Patacchini, Romina Nassini, Serena Materazzi

Published in: Lung | Special Issue 1/2010

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Abstract

Sneezing, cough, mucus secretion, and bronchoconstriction represent the main components of a coordinated and efficient reaction direct to expel or neutralize irritant agents from the respiratory system. A dense network of sensory nerves localized from the nose to the lower airways beneath the epithelium subserves this function. A variety of receptors and channels present in sensory nerve terminals by sensing irritant stimuli activate the system in emergence and initiate protective reflex responses, including cough. Previous and recent literature highlights the prominent role of some transient receptor potential (TRP) ion channels, and specifically the vanilloid 1 (TRPV1) and the ankyrin 1 (TRPA1) as sensors of airway irritation and initiators of the cough reflex.
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Metadata
Title
Cough: The Emerging Role of the TRPA1 Channel
Authors
Pierangelo Geppetti
Riccardo Patacchini
Romina Nassini
Serena Materazzi
Publication date
01-01-2010
Publisher
Springer-Verlag
Published in
Lung / Issue Special Issue 1/2010
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-009-9201-3

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