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Published in: Clinical and Translational Allergy 1/2015

Open Access 01-12-2015 | Review

Cough hypersensitivity as a neuro-immune interaction

Authors: Woo-Jung Song, Yoon-Seok Chang

Published in: Clinical and Translational Allergy | Issue 1/2015

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Abstract

Cough is an intrinsic protective reflex. However, chronic cough affects a considerable proportion of general population and has a major impact on quality of life. A recent paradigm shift to ‘cough hypersensitivity syndrome’ suggests that chronic cough arises from hypersensitivity of the airway sensory nerves. As cough reflex is determined by interaction of the nervous system with immune system, persistent dysregulation of one or both of these systems may lead to chronic cough hypersensitivity. Here we review the current evidence for the neuro-immune interactions that underlie cough hypersensitivity and discuss future therapeutic strategies.
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Metadata
Title
Cough hypersensitivity as a neuro-immune interaction
Authors
Woo-Jung Song
Yoon-Seok Chang
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Clinical and Translational Allergy / Issue 1/2015
Electronic ISSN: 2045-7022
DOI
https://doi.org/10.1186/s13601-015-0069-4

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Reviewer acknowledgement

Reviewer acknowledgement 2014