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PharmacoEconomics
Published in: PharmacoEconomics 11/2001

01-11-2001 | Original Research Article

Cost Effectiveness of Treatment Options in Advanced Breast Cancer in the UK

Authors: Dr Ruth E. Brown, John Hutton, Anita Burrell

Published in: PharmacoEconomics | Issue 11/2001

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Abstract

Objective: To compare clinical and economic study data for docetaxel, paclitaxel and vinorelbine in the treatment of anthracycline-resistant advanced breast cancer.
Study design and methods: A Markov decision-analysis model to simulate the clinical course of a ‘typical’ patient with advanced breast cancer during salvage chemotherapy was updated with response rates and adverse effect rates from phase III clinical trial data for docetaxel, paclitaxel and vinorelbine. Costs were taken from UK national databases and hospitals. Utilities were estimated from 30 oncology nurses in the UK using the standard gamble method.
Perspective: National Health Service.
Results: When compared with other chemotherapeutic agents, docetaxel has been shown to increase response rate, time to progression and survival in patients with advanced breast cancer. In the base-case analysis, the incremental cost-utility ratio for docetaxel versus paclitaxel was £1995 per quality-adjusted life year (QALY) gained (1998 values). The incremental cost-utility ratio for docetaxel versus vinorelbine was £14 055 per QALY gained. In the comparison with vinorelbine, docetaxel provided the equivalent of an additional 92 days of perfect health. Sensitivity analyses confirmed the robustness of the model and the validity of the base-case analysis results. Even in the worst case scenarios, docetaxel remained cost effective compared with paclitaxel and vinorelbine.
Conclusions: These findings support the use of the taxoids, notably docetaxel, in the management of advanced breast cancer.
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Metadata
Title
Cost Effectiveness of Treatment Options in Advanced Breast Cancer in the UK
Authors
Dr Ruth E. Brown
John Hutton
Anita Burrell
Publication date
01-11-2001
Publisher
Springer International Publishing
Published in
PharmacoEconomics / Issue 11/2001
Print ISSN: 1170-7690
Electronic ISSN: 1179-2027
DOI
https://doi.org/10.2165/00019053-200119110-00003

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