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01-02-2018 | Gynecologic Oncology

Correlation between NM23 protein overexpression and prognostic value and clinicopathologic features of ovarian cancer: a meta-analysis

Authors: Jie Fang, Xueke Guo, Bo Zheng, Wei Han, Xia Chen, Jiawei Zhu, Bing Xie, Jiajia Liu, Xiaojin Luan, Yidan Yan, Zeyu He, Hong Li, Chen Qiao, Jun Yu

Published in: Archives of Gynecology and Obstetrics | Issue 2/2018

Abstract

Objective

The prognostic value and clinicopathological features of NM23 (non-metastasis 23) have previously been assessed, but the results are controversial. Here, we attempted to clarify the correlation between NM23 expression and its prognostic value and the clinicopathological features in ovarian cancer (OC).

Methods

The relevant studies were identified using PubMed, Embase, and Web of Science. We calculated the pooled odds ratio (OR) with 95% confidence intervals (CIs) for overall survival (OS), progression-free survival (PFS), and clinicopathological features. We used OS to evaluate the prognostic value of NM23 expression in patients with OC. Subgroup analyses were used to explore the source of heterogeneity.

Results

We included 10 studies involving 894 patients in our assessment of the association between NM23 expression and OS for OC. Our data indicated that NM23 expression was not associated with improved OS (OR 0.83, 95% CI 0.41–1.68, P = 0.61) or PFS (OR 0.7, 95% CI 0.39–1.24, P = 0.22). Elevated NM23 expression was associated with differentiation grade (OR 0.35, 95% CI 0.2–0.6, P = 0.0002) and N status (OR 0.33, 95% CI 0.14–0.78, P = 0.01), whereas there was no significant difference between NM23 expression and tumor stage (OR 1.1, 95% CI 0.45–2.66, P = 0.84). Subgroup analysis did not reveal any potential source of heterogeneity. No obvious publication bias was found.

Conclusions

In OC, there is poor statistical significance between NM23 expression and OS and PFS, but NM23 expression is related to differentiation grade and N status. This meta-analysis reveals that NM23 expression is a potential factor of poor prognosis in OC. The prognostic role of NM23 in different OC stages in combination with the clinical characteristics suggests a novel approach for developing future therapeutic targets.

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Title: Correlation between NM23 protein overexpression and prognostic value and clinicopathologic features of ovarian cancer: a meta-analysis
Authors: Jie Fang
Xueke Guo
Bo Zheng
Wei Han
Xia Chen
Jiawei Zhu
Bing Xie
Jiajia Liu
Xiaojin Luan
Yidan Yan
Zeyu He
Hong Li
Chen Qiao
Jun Yu
Publication date: 01-02-2018
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 2/2018
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4620-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Correlation between NM23 protein overexpression and prognostic value and clinicopathologic features of ovarian cancer: a meta-analysis

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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