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Open Access 01-12-2017 | Original Article

Correlation between E-cadherin and p120 expression in invasive ductal breast cancer with a lobular component and MRI findings

Authors: Mary-Ann El Sharouni, Emily L. Postma, Paul J. van Diest

Published in: Virchows Archiv | Issue 6/2017

Abstract

Invasive breast cancer comprises a spectrum of histological changes with purely lobular cancer on one side and purely ductal cancer on the other, with many mixed lesions in between. In a previous study, we showed that in patients with any percentage lobular component at core needle biopsy, preoperative MRI leads to the detection of clinically relevant additional findings in a substantial percentage of patients, irrespective of the percentage of the lobular component. Detection of a small lobular component may however not be reproducible among pathologists. Loss of membrane expression of E-cadherin or p120 is useful biomarkers of ILC and may therefore support a more objective diagnosis. All patients diagnosed with breast cancer containing a lobular component of any percentage between January 2008 and October 2012 were prospectively offered preoperative MRI. Clinically relevant additional findings on MRI were verified by pathology evaluation. Expression patterns of E-cadherin and p120 were evaluated by immunohistochemistry on the core needle biopsy. MRI was performed in 109 patients. The percentage of lobular component was significantly increased in cases with aberrant E-cadherin or p120 expression (both p = <0.001). However, aberrant expression of E-cadherin and p120 was not related to the probability of detecting relevant additional MRI findings. E-cadherin and p120 did not appear to be useful objective biomarkers for predicting additional relevant findings on MRI in patients with a lobular component in the core needle of their breast cancer.

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Title: Correlation between E-cadherin and p120 expression in invasive ductal breast cancer with a lobular component and MRI findings
Authors: Mary-Ann El Sharouni
Emily L. Postma
Paul J. van Diest
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 6/2017
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-017-2203-2

At a glance: The STEP trials

Springer Medicine

Correlation between E-cadherin and p120 expression in invasive ductal breast cancer with a lobular component and MRI findings

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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