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Clinical Orthopaedics and Related Research®

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01-01-2017 | CORR Insights

CORR Insights^®: No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA

Authors: Philippe Richebé, MD, PhD, Véronique Brulotte, MD, MSc

Published in: Clinical Orthopaedics and Related Research® | Issue 1/2017

Excerpt

The randomized controlled trial by Barrington and colleagues raises new questions about the utility of using liposomal bupivacaine-based periarticular injection (PAI) (Exparel; Pacira Pharmaceuticals, Parsippany, NJ, USA) to improve pain management after TKA, as the only benefit was a decrease in the postoperative itching from 38% to 15% when intrathecal morphine was not injected. This randomized controlled trial also shows that interventions such as intraarticular addition of extended-release liposomal bupivacaine or intrathecal morphine do not clearly improve pain profiles or opioid requirements after TKA surgery when compared to a PAI with standard bupivacaine and associated with multimodal analgesia including acetaminophen, Celebrex (G.D. Searle LLC Division of Pfizer Inc, New York, NY, USA), OxyContin (Purdue Pharma LP, Stamford, CT, USA), and Decadron (Merck & Co Inc, Kenilworth, NJ, USA). This raises the real question: Is there still room for liposomal bupivacaine in TKA surgery? …

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Title: CORR Insights®: No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA
Authors: Philippe Richebé, MD, PhD
Véronique Brulotte, MD, MSc
Publication date: 01-01-2017
Publisher: Springer US
Published in: Clinical Orthopaedics and Related Research® / Issue 1/2017
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-016-4986-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

CORR Insights^®: No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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