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01-03-2021 | Coronavirus | Brief Report

Replicative capacity of four porcine enteric coronaviruses in LLC-PK1 cells

Authors: Wenwen Xiao, Xunlei Wang, Jing Wang, Puxian Fang, Shaobo Xiao, Liurong Fang

Published in: Archives of Virology | Issue 3/2021

Abstract

Enteric coronaviruses (CoVs) are major pathogens that cause diarrhea in piglets. To date, four porcine enteric CoVs have been identified: transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and HKU2-like porcine enteric alphacoronavirus (PEAV). In this study, we investigated the replicative capacity of these four enteric CoVs in LLC-PK1 cells, a porcine kidney cell line. The results showed that LLC-PK1 cells are susceptible to all four enteric CoVs, particularly to TGEV and PDCoV infections, indicating that LLC-PK1 cells can be applied to porcine enteric CoV research in vitro, particularly for coinfection studies.

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Title: Replicative capacity of four porcine enteric coronaviruses in LLC-PK1 cells
Authors: Wenwen Xiao
Xunlei Wang
Jing Wang
Puxian Fang
Shaobo Xiao
Liurong Fang
Publication date: 01-03-2021
Publisher: Springer Vienna
Keyword: Coronavirus
Published in: Archives of Virology / Issue 3/2021
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-020-04947-2

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