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Published in: BMC Infectious Diseases 1/2020

01-12-2020 | Coronavirus | Case report

Neurogenic pulmonary edema following febrile status epilepticus in a 22-month-old infant with multiple respiratory virus co-detection: a case report

Authors: Yoshie Takagi, Takeaki Imamura, Shota Endo, Kenta Hayashi, Satoka Akiyama, Yoji Ikuta, Takahiro Kawaguchi, Tomoko Sumita, Tatsuo Katori, Masanori Hashino, Shinji Saito, Takato Odagiri, Kunihiro Oba, Makoto Kuroda, Tsutomu Kageyama

Published in: BMC Infectious Diseases | Issue 1/2020

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Abstract

Background

Neurogenic pulmonary edema is a rare but serious complication of febrile status epilepticus in children. Comprehensive screening for viral pathogens is seldomly performed in the work-up of febrile children.

Case presentation

A 22-month-old girl presented with her first episode of febrile status epilepticus, after which she developed acute pulmonary edema and respiratory failure. After the termination of seizure activity, the patient was intubated and managed on mechanical ventilation in the emergency room. The resolution of respiratory failure, as well as the neurological recovery, was achieved 9 h after admission, and the patient was discharged 6 days after admission without any complications. Molecular biological diagnostic methods identified the presence of human coronavirus HKU1, influenza C virus, and human parainfluenza virus 2 from the patient’s nasopharyngeal specimens.

Conclusions

Neurogenic pulmonary edema following febrile status epilepticus was suspected to be the etiology of our patient’s acute pulmonary edema and respiratory failure. Timely seizure termination and rapid airway and respiratory intervention resulted in favorable outcomes of the patient. Molecular biological diagnostic methods identified three respiratory viruses; however, their relevance and association with clinical symptoms remain speculative.
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Metadata
Title
Neurogenic pulmonary edema following febrile status epilepticus in a 22-month-old infant with multiple respiratory virus co-detection: a case report
Authors
Yoshie Takagi
Takeaki Imamura
Shota Endo
Kenta Hayashi
Satoka Akiyama
Yoji Ikuta
Takahiro Kawaguchi
Tomoko Sumita
Tatsuo Katori
Masanori Hashino
Shinji Saito
Takato Odagiri
Kunihiro Oba
Makoto Kuroda
Tsutomu Kageyama
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2020
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-020-05115-2

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