Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Neurological Sciences
Published in: Neurological Sciences 7/2021

01-07-2021 | Coronavirus | Original Article

Assessment of mental health, knowledge, and attitude of patients with multiple sclerosis and neuromyelitis optica spectrum disorder in response to 2019 novel coronavirus

Authors: Vahid Shaygannejad, Alireza Afshari-Safavi, Boshra Hatef

Published in: Neurological Sciences | Issue 7/2021

Login to get access

Abstract

Background

With the recent pandemic of the novel coronavirus disease (COVID-19), multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) patients for their compromised immune system have been in significant concern. Awareness and attitude about this virus have an important impact on infection prevention and coping with stress and anxiety. So we conducted this study to assess knowledge, attitude, and mental health status in MS and NMOSD patients within the COVID-19 pandemic.

Method

In this cross-sectional study, the link of Depression Anxiety Stress Scales-21 (DASS-21) and a self-administered structured questionnaire were sent through social media to MS and NMOSD patients and two control groups consisting of healthy and migraine individuals.

Results

A total of 223 MS patients, 41 NMOSD, 29 migraine, and 245 healthy subjects participated in this study. MS patients had higher total DASS scores compared to healthy participants (p = 0.012). There were no significant differences among the study groups regarding knowledge and attitude. In MS patients, physical comorbidity was associated with a total score of attitude (OR 1.59, 95% CI 0.53, 2.66, p = 0.004). We did not find association between other demographic and clinical variables with DASS scores, attitude, and knowledge in MS patients.

Conclusion

The current data highlight the necessity of attitude, knowledge, and mental health assessment among MS and NMOSD patients. Further studies in other countries need to be carried to assess these points among MS and NMOSD patients.
Literature
1.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395(10223):497–506CrossRef
2.
3.
4.
Epstein DJ, Dunn J, Deresinski S (2018) Infectious complications of multiple sclerosis therapies: implications for screening, prophylaxis, and management. Open Forum Infect Dis: Oxford University Press US 5:ofy174CrossRef
5.
Zhu L, Xu X, Ma K, Yang J, Guan H, Chen S, Chen Z, Chen G (2020) Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression. Am J Transplant 20:1859–1863CrossRef
6.
Ghajarzadeh M, Bonavita S (2020) Are patients with multiple sclerosis (MS) at higher risk of COVID-19 infection? Neurol Sci 41(9):2315–2316CrossRef
7.
Dalla Costa G, Leocani L, Montalban X, Guerrero AI, Sørensen PS, Magyari M et al (2020) Real-time assessment of COVID-19 prevalence among multiple sclerosis patients: a multicenter European study. Neurol Sci 41(7):1647–1650CrossRef
8.
Louapre C, Collongues N, Stankoff B, Giannesini C, Papeix C, Bensa C, Deschamps R, Créange A, Wahab A, Pelletier J, Heinzlef O, Labauge P, Guilloton L, Ahle G, Goudot M, Bigaut K, Laplaud DA, Vukusic S, Lubetzki C, de Sèze J, for the Covisep investigators (2020) Clinical characteristics and outcomes in patients with coronavirus disease 2019 and multiple sclerosis. JAMA Neurol 77(9):1079–1088CrossRef
9.
Devogelaere J, D’hooghe MB, Vanderhauwaert F, D’haeseleer M (2020) Coronavirus disease 2019: favorable outcome in an immunosuppressed patient with multiple sclerosis. Neurol Sci 41(8):1981–1983CrossRef
10.
Beiske A, Svensson E, Sandanger I, Czujko B, Pedersen E, Aarseth J et al (2008) Depression and anxiety amongst multiple sclerosis patients. Eur J Neurol 15(3):239–245CrossRef
11.
Buljevac D, Hop W, Reedeker W, Janssens A, Van der Meche F, Van Doorn P et al (2003) Self reported stressful life events and exacerbations in multiple sclerosis: prospective study. Bmj. 327(7416):646–640CrossRef
12.
Brown R, Tennant C, Sharrock M, Hodgkinson S, Dunn S, Pollard J (2006) Relationship between stress and relapse in multiple sclerosis: part II. Direct and indirect relationships. Mult Scler J 12(4):465–475CrossRef
13.
Chanson JB, Zéphir H, Collongues N, Outteryck O, Blanc F, Fleury M, Vermersch P, de Seze J (2011) Evaluation of health-related quality of life, fatigue and depression in neuromyelitis optica. Eur J Neurol 18(6):836–841CrossRef
14.
Roy D, Tripathy S, Kar SK, Sharma N, Verma SK, Kaushal V (2020) Study of knowledge, attitude, anxiety & perceived mental healthcare need in Indian population during COVID-19 pandemic. Asian J Psychiatr 51:102083CrossRef
15.
16.
Moghadasi N (2020) Evaluation of the level of anxiety among Iranian multiple sclerosis fellowships during the outbreak of COVID-19. Arch Iran Med 23(4):283CrossRef
17.
Shanafelt T, Ripp J, Trockel M (2020) Understanding and addressing sources of anxiety among health care professionals during the COVID-19 pandemic. Jama. 323:2133–2134CrossRef
18.
19.
20.
21.
22.
Javanmard SH, Nasirian M, Ataei B, Vaseghi G, Vaezi A, Changiz T (2020) Isfahan COvid-19 REgistry (I-CORE): design and methodology. J Res Med Sci 25(1):32CrossRef
23.
24.
Sahraian MA, Azimi A, Navardi S, Ala S, Moghadasi AN (2020) Evaluation of the rate of COVID-19 infection, hospitalization and death among Iranian patients with multiple sclerosis. Mult Scler Relat Disord 46:102472CrossRef
25.
Safavi F, Nourbakhsh B, Azimi AR (2020) B-cell depleting therapies may affect susceptibility to acute respiratory illness among patients with multiple sclerosis during the early COVID-19 epidemic in Iran. Mult Scler Relat Disord 43:102195CrossRef
26.
Barzegar M, Mirmosayyeb O, Ghajarzadeh M, Nehzat N, Vaheb S, Shaygannejad V, Vosoughi R (2020) Characteristics of COVID-19 disease in multiple sclerosis patients. Mult Scler Relat Disord 45:102276CrossRef
27.
28.
Mirmosayyeb O, Vaheb S, Barzegar M, Shaygannejad V, Bonavita S, Ghajarzadeh M (2020) Screening neuromyelitis optica patients for COVID-19 infection. Autoimmun Rev 19:102669CrossRef
29.
McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD et al (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol 50(1):121–127CrossRef
30.
Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, Lublin FD, Metz LM, McFarland HF, O'Connor PW, Sandberg-Wollheim M, Thompson AJ, Weinshenker BG, Wolinsky JS (2005) Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald criteria”. Ann Neurol 58(6):840–846CrossRef
31.
Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O'Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS (2011) Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 69(2):292–302CrossRef
32.
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA (2018) Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 17(2):162–173CrossRef
33.
Wingerchuk DM, Lennon VA, Pittock SJ, Lucchinetti CF, Weinshenker BG (2006) Revised diagnostic criteria for neuromyelitis optica. Neurology. 66(10):1485–1489CrossRef
34.
Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG, International Panel for NMO Diagnosis (2015) International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 85(2):177–189CrossRef
35.
Parodi IC, Poeta MG, Assini A, Schirinzi E, Del Sette P (2020) Impact of quarantine due to COVID infection on migraine: a survey in Genova, Italy. Neurol Sci 41(8):2025–2027CrossRef
36.
Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33(11):1444CrossRef
37.
Henry JD, Crawford JR (2005) The short-form version of the depression anxiety stress scales (DASS-21): construct validity and normative data in a large non-clinical sample. Br J Clin Psychol 44(2):227–239CrossRef
38.
Asghari A, Saed F, Dibajnia P (2008) Psychometric properties of the depression anxiety stress scales-21 (DASS-21) in a non-clinical Iranian sample. Int J Psychol 2(2):82–102
39.
Abbasian H, Hajimolaali M, Yektadoost A, Zartab S (2019) Antibiotic utilization in Iran 2000–2016: pattern analysis and benchmarking with organization for economic co-operation and development countries. J Res Pharm Pract 8(3):162–167CrossRef
40.
Jamhour A, El-Kheir A, Salameh P, Hanna PA, Mansour H (2017) Antibiotic knowledge and self-medication practices in a developing country: a cross-sectional study. Am J Infect Control 45(4):384–388CrossRef
41.
Enato EF, Sounyo AA, Einarson TR (2011) Medication utilization and illness management study in Nigeria. Ann Pharmacother 45(7–8):924–930CrossRef
42.
Torres N, Chibi B, Middleton L, Solomon V, Mashamba-Thompson T (2019) Evidence of factors influencing self-medication with antibiotics in low and middle-income countries: a systematic scoping review. Public Health 168:92–101CrossRef
43.
Hosseinzadeh K, Azimian J (2017) Iranians’ self-report knowledge and practice about arbitrary use of antibiotics. J Clin Diagn Res 11(8):FC06–FC09PubMedPubMedCentral
44.
Borges do Nascimento IJ, Cacic N, Abdulazeem HM, von Groote TC, Jayarajah U, Weerasekara I, Esfahani MA, Civile VT, Marusic A, Jeroncic A, Carvas Junior N, Pericic TP, Zakarija-Grkovic I, Meirelles Guimarães SM, Luigi Bragazzi N, Bjorklund M, Sofi-Mahmudi A, Altujjar M, Tian M, Arcani DMC, O’Mathúna DP, Marcolino MS (2020) Novel coronavirus infection (COVID-19) in humans: a scoping review and meta-analysis. J Clin Med 9(4):941. https://​doi.​org/​10.​3390/​jcm9040941
45.
Lan L, Xu D, Ye G, Xia C, Wang S, Li Y, Xu H (2020) Positive RT-PCR test results in patients recovered from COVID-19. Jama. 323:1502–1503CrossRef
46.
Everts J (2013) Announcing swine flu and the interpretation of pandemic anxiety. Antipode. 45(4):809–825CrossRef
47.
Banerjee D (2020) The COVID-19 outbreak: crucial role the psychiatrists can play. Asian J Psychiatr 50:102014CrossRef
48.
49.
50.
51.
52.
53.
Cohen BH, Busis NA, Ciccarelli L (2020) Coding in the world of COVID-19: non–face-to-face evaluation and management care. Continuum. 26(3):1–25
54.
Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, Rubin GJ (2020) The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 395:912–920CrossRef
55.
56.
D'Antiga L (2020) Coronaviruses and immunosuppressed patients. The facts during the third epidemic. Liver Transpl 26:832–834CrossRef
57.
Wijnands JM, Kingwell E, Zhu F, Zhao Y, Fisk JD, Evans C et al (2017) Infection-related health care utilization among people with and without multiple sclerosis. Mult Scler J 23(11):1506–1516CrossRef
58.
Corallo F, Buono VL, Genovese R, Palmeri R, Di Cara M, Rifici C et al (2019) A complex relation between depression and multiple sclerosis: a descriptive review. Neurol Sci 40(8):1551–1558
Metadata
Title
Assessment of mental health, knowledge, and attitude of patients with multiple sclerosis and neuromyelitis optica spectrum disorder in response to 2019 novel coronavirus
Authors
Vahid Shaygannejad
Alireza Afshari-Safavi
Boshra Hatef
Publication date
01-07-2021
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 7/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-020-04905-5

Other articles of this Issue 7/2021

Neurological Sciences 7/2021 Go to the issue

COVID-19

Virtual visits for chronic neurologic disorders during COVID-19 pandemic

Letter to the Editor

Deep brain stimulation in Fragile X syndrome with tardive dystonia

COVID-19

Neuro-telehealth for fragile patients in a tertiary referral neurological institute during the COVID-19 pandemic in Milan, Lombardy

Original Article

Adults with severe Japanese encephalitis: a retrospective analysis of 9 cases in Linyi, China

Review Article

Peripheral nervous system in multiple sclerosis—understanding the involvement via autonomic nervous system

Letter to the Editor

Person-in-the-barrel syndrome: a new type of epilepsy-related injury