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01-11-2020 | Coronavirus | COVID-19

Neuromuscular presentations in patients with COVID-19

Authors: Vimal Kumar Paliwal, Ravindra Kumar Garg, Ankit Gupta, Nidhi Tejan

Published in: Neurological Sciences | Issue 11/2020

Abstract

COVID-19 is caused by the coronavirus SARS-CoV-2 that has an affinity for neural tissue. There are reports of encephalitis, encephalopathy, cranial neuropathy, Guillain-Barrè syndrome, and myositis/rhabdomyolysis in patients with COVID-19. In this review, we focused on the neuromuscular manifestations of SARS-CoV-2 infection. We analyzed all published reports on SARS-CoV-2-related peripheral nerve, neuromuscular junction, muscle, and cranial nerve disorders. Olfactory and gustatory dysfunction is now accepted as an early manifestation of COVID-19 infection. Inflammation, edema, and axonal damage of olfactory bulb have been shown in autopsy of patients who died of COVID-19. Olfactory pathway is suggested as a portal of entry of SARS-CoV-2 in the brain. Similar to involvement of olfactory bulb, isolated oculomotor, trochlear and facial nerve has been described. Increasing reports Guillain-Barrè syndrome secondary to COVID-19 are being published. Unlike typical GBS, most of COVID-19-related GBS were elderly, had concomitant pneumonia or ARDS, more prevalent demyelinating neuropathy, and relatively poor outcome. Myalgia is described among the common symptoms of COVID-19 after fever, cough, and sore throat. Duration of myalgia may be related to the severity of COVID-19 disease. Few patients had muscle weakness and elevated creatine kinase along with elevated levels of acute-phase reactants. All these patients with myositis/rhabdomyolysis had severe respiratory complications related to COVID-19. A handful of patients with myasthenia gravis showed exacerbation of their disease after acquiring COVID-19 disease. Most of these patients recovered with either intravenous immunoglobulins or steroids.

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Title: Neuromuscular presentations in patients with COVID-19
Authors: Vimal Kumar Paliwal
Ravindra Kumar Garg
Ankit Gupta
Nidhi Tejan
Publication date: 01-11-2020
Publisher: Springer International Publishing
Keywords: Coronavirus
Guillain-Barré Syndrome
Myalgie
Cough
Myalgia
SARS-CoV-2
Cough
Cough
COVID-19
Anosmia
Published in: Neurological Sciences / Issue 11/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04708-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Neuromuscular presentations in patients with COVID-19

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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