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Open Access 01-12-2022 | Coronary Heart Disease | Research article

Associations of handgrip strength with morbidity and all-cause mortality of cardiometabolic multimorbidity

Authors: Yanqiang Lu, Guochen Li, Pietro Ferrari, Heinz Freisling, Yanan Qiao, Luying Wu, Liping Shao, Chaofu Ke

Published in: BMC Medicine | Issue 1/2022

Abstract

Background

Cardiometabolic multimorbidity (CM) is an increasing public health and clinical concern. However, predictors for the development and prognosis of CM are poorly understood. The aims of this study were to investigate the relation between handgrip strength (HGS) and the risk of CM and to examine the association of HGS with all-cause mortality risk among patients with CM.

Methods

This prospective cohort study involved 493,774 participants from the UK Biobank. CM was defined as the simultaneous occurrence of two or more of the following conditions: type 2 diabetes, stroke, and coronary heart disease (CHD). Cox proportional hazards models were performed to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs).

Results

During a median follow-up of 12.1 years, 4701 incident CM cases were documented among participants with none cardiometabolic disease at baseline. Compared with the fourth quartile (Q4), the multivariable adjusted HR (95% CI) value of Q1 of HGS for developing CM was 1.46 (1.34–1.60). In participants with one cardiometabolic disease at baseline, participants in Q1 of HGS also possessed higher risk of CM than those in Q4, with HRs (95% CIs) being 1.35 (1.23–1.49) in patients with type 2 diabetes, 1.23 (1.04–1.46) in patients with stroke, and 1.23 (1.11–1.36) in patients with CHD. For participants with CM at recruitment, HGS was also associated with the risk of all-cause mortality (Q1 vs. Q4 HR: 1.57, 95% CI: 1.36–1.80).

Conclusions

Our study provided novel evidence that HGS could be an independent predictor of morbidity and all-cause mortality of CM.

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Title: Associations of handgrip strength with morbidity and all-cause mortality of cardiometabolic multimorbidity
Authors: Yanqiang Lu
Guochen Li
Pietro Ferrari
Heinz Freisling
Yanan Qiao
Luying Wu
Liping Shao
Chaofu Ke
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Coronary Heart Disease
Stroke
Type 2 Diabetes
Published in: BMC Medicine / Issue 1/2022
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/s12916-022-02389-y

At a glance: The STEP trials

Springer Medicine

Associations of handgrip strength with morbidity and all-cause mortality of cardiometabolic multimorbidity

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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