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Cardiovascular Diabetology
Published in: Cardiovascular Diabetology 1/2024

Open Access 01-12-2024 | Coronary Heart Disease | Research

The relationship between triglyceride-glucose index and prospective key clinical outcomes in patients hospitalised for coronary artery disease

Authors: Benchuan Hao, Lyu Lyu, Juan Xu, Xiaoqing Zhu, Cui Xu, Weiyang Gao, Ji Qin, Taoke Huang, Yipu Ding, Ziyue Zhang, Yanhui Yang, Hongbin Liu

Published in: Cardiovascular Diabetology | Issue 1/2024

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Abstract

Background

The triglyceride-glucose (TyG) index is regarded as a dependable alternative for assessing insulin resistance (IR), given its simplicity, cost-effectiveness, and strong correlation with IR. The relationship between the TyG index and adverse outcomes in patients with coronary heart disease (CHD) is not well established. This study examines the association of the TyG index with long-term adverse outcomes in hospitalized CHD patients.

Methods

In this single-center prospective cohort study, 3321 patients hospitalized with CHD were included. Multivariate Cox regression models were employed to assess the associations between the TyG index and the incidence of all-cause mortality and major adverse cardiovascular events (MACEs). To examine potential nonlinear associations, restricted cubic splines and threshold analysis were utilized.

Results

During a follow-up period of 9.4 years, 759 patients (22.9%) succumbed to mortality, while 1291 (38.9%) experienced MACEs. Threshold analysis demonstrated a significant “U”-shaped nonlinear relationship with MACEs, with different hazard ratios observed below and above a TyG index of 8.62 (below: HR 0.71, 95% CI 0.50–0.99; above: HR 1.28, 95% CI 1.10–1.48). Notably, an increased risk of all-cause mortality was observed only when the TyG index exceeded 8.77 (HR 1.53, 95% CI 1.19–1.96).

Conclusions

This study reveals a nonlinear association between the TyG index and both all-cause mortality and MACEs in hospitalized CHD patients with CHD. Assessing the TyG index, particularly focusing on individuals with extremely low or high TyG index values, may enhance risk stratification for adverse outcomes in this patient population.
Appendix
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Metadata
Title
The relationship between triglyceride-glucose index and prospective key clinical outcomes in patients hospitalised for coronary artery disease
Authors
Benchuan Hao
Lyu Lyu
Juan Xu
Xiaoqing Zhu
Cui Xu
Weiyang Gao
Ji Qin
Taoke Huang
Yipu Ding
Ziyue Zhang
Yanhui Yang
Hongbin Liu
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2024
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/s12933-024-02132-2

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