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Angiogenesis
Published in: Angiogenesis 2/2014

01-04-2014 | Review Paper

Control of dendritic cell trafficking in lymphatics by chemokines

Authors: Louise A. Johnson, David G. Jackson

Published in: Angiogenesis | Issue 2/2014

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Abstract

Dendritic cells (DCs) are crucial participants in maintaining immune surveillance of the periphery and initiating primary immune responses within the draining lymph nodes. The afferent lymphatic vessels provide a conduit for this essential trafficking and, as this review will describe, play an active role in regulating DC migration. Afferent lymphatic capillaries support constitutive trafficking of DCs from resting, non-inflamed tissue, to maintain tolerance against self-antigen and to provide immune surveillance. Following exposure to pathogens or pro-inflammatory cytokines, DCs mature from phagocytes to professional antigen-presenting cells, whilst the lymphatic endothelium adopts an activated phenotype to support the ensuing increase in leukocyte trafficking. The lymphatic endothelial-derived chemokine CCL21 plays a well-characterized role in directing migration of CCR7+ DC in both resting and acute inflammatory conditions. However, efficient trafficking of DCs from inflamed tissue also demands additional chemokine-receptor pairs. Thus, entry of DCs to activated lymphatic vessels is an intricately regulated multi-step process involving numerous chemokines and adhesion molecules.
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Metadata
Title
Control of dendritic cell trafficking in lymphatics by chemokines
Authors
Louise A. Johnson
David G. Jackson
Publication date
01-04-2014
Publisher
Springer Netherlands
Published in
Angiogenesis / Issue 2/2014
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-013-9407-0

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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