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Modern Rheumatology
Published in: Modern Rheumatology 3/2008

01-06-2008 | Review Article

Control of chondrogenesis by the transcription factor Sox9

Author: Haruhiko Akiyama

Published in: Modern Rheumatology | Issue 3/2008

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Abstract

Cell-fate determination of pluripotent cells, cell proliferation, differentiation, and maturation, as well as the maintenance of stem cells, are essential cellular events during organogenesis. Previous reports show that some distinct cell-specific transcription factors are the master genes that control cell lineage commitment and the subsequent cell proliferation and differentiation. Some of these transcription factors generate hierarchical regulation of expression and act in concert to fulfill their roles. This review discusses the molecular properties and mechanisms of Sry-related high-mobility-group box (Sox) transcription factor, Sox9, in chondrogenesis.
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Metadata
Title
Control of chondrogenesis by the transcription factor Sox9
Author
Haruhiko Akiyama
Publication date
01-06-2008
Publisher
Springer Japan
Published in
Modern Rheumatology / Issue 3/2008
Print ISSN: 1439-7595
Electronic ISSN: 1439-7609
DOI
https://doi.org/10.1007/s10165-008-0048-x

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