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Tumor Biology
Published in: Tumor Biology 1/2016

01-01-2016 | Original Article

Contribution of resident and recruited macrophages to the photodynamic intervention of colorectal tumor microenvironment

Authors: María Florencia Pansa, María Julia Lamberti, Ingrid Sol Cogno, Silvia Graciela Correa, Natalia Belén Rumie Vittar, Viviana Alicia Rivarola

Published in: Tumor Biology | Issue 1/2016

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Abstract

The study of cellular interactions in the tumor microenvironment has become one of the main areas of research in the fight against cancer. Tumor-associated macrophages (TAMs) influence tumor progression and therapy response due to its functional plasticity. Regarding cancer treatment, photodynamic therapy (PDT) is a minimally invasive and clinically approved procedure that involves the administration of a photosensitizer (PS), a nontoxic photosensitizing drug which is selectively retained in neoplastic tissue. Here, we investigated the role of resident and nonresident macrophages in the context of a PDT-treated colorectal tumor by developing a combination of 2-D and three-dimensional (3-D) experimental platform, recreating tumor-stroma interactions in vitro. Enhancement of cytotoxicity of PDT was achieved in the presence of nonresident macrophages which had a strong anti-tumor phenotype mediated by the production of nitric oxide, IL-6, and tumor necrosis factor alpha (TNF-α). On the contrary, tumor resident macrophages induced a pro-tumor phenotype promoting tumor cell migration and endothelial stimulation. Due to their plasticity, tumor-resident or tumor-recruited macrophages can differentially influence the response of tumors to PDT, so their multifactorial roles should be considered in the overall design of anti-tumor therapeutic.
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Metadata
Title
Contribution of resident and recruited macrophages to the photodynamic intervention of colorectal tumor microenvironment
Authors
María Florencia Pansa
María Julia Lamberti
Ingrid Sol Cogno
Silvia Graciela Correa
Natalia Belén Rumie Vittar
Viviana Alicia Rivarola
Publication date
01-01-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 1/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3768-5

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