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World Journal of Surgery
Published in: World Journal of Surgery 9/2008

01-09-2008

Continuing Debate on D2 Lymphadenectomy for Gastric Cancer

Authors: Dimosthenis Ziogas, George Baltogiannis, Michael Fatouros

Published in: World Journal of Surgery | Issue 9/2008

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Excerpt

Despite the favorable results with extended (D2) lymph node dissection from specialized institutions [1, 2], there is no end to the debate about the optimal extent of surgery for nonmetastatic gastric cancer [3‐5]. D2 lymphadenectomy has been the standard procedure in East Asian countries, particularly in Japan and Korea. Multiple retrospective studies, including analyses of data from large databases, that have been recently reviewed [6, 7] and a recent randomized, relatively small, phase III clinical trial from Taiwan [8] have shown an overall survival for all curatively resected patients; subgroup analysis has also demonstrated a survival benefit in both stage II and stage III disease [9‐11]. However, in Western countries, previous randomized clinical trials (RCTs) failed to demonstrate an overall survival benefit, and at present there is no level I evidence from RCTs or outside specialized Western institutions of the survival benefit of D2 dissection. …
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Metadata
Title
Continuing Debate on D2 Lymphadenectomy for Gastric Cancer
Authors
Dimosthenis Ziogas
George Baltogiannis
Michael Fatouros
Publication date
01-09-2008
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 9/2008
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-008-9645-2

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