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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 2/2018

01-02-2018 | Concise Commentary

Concise Commentary: Is Nrf2 a Master Regulator of Intestinal Fibrosis?

Author: Giovanni Latella

Published in: Digestive Diseases and Sciences | Issue 2/2018

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Excerpt

Intestinal fibrosis becomes clinically evident in approximately 40% of patients with Crohn’s disease (CD) and in 5% of those with ulcerative colitis (UC). Fibrosis, a consequence of local chronic inflammation, is characterized by excessive deposition of extracellular matrix (ECM) protein. …
Literature
1.
Latella G, Di Gregorio J, Flati V, Rieder F, Lawrance IC. Mechanisms of initiation and progression of intestinal fibrosis in IBD. Scand J Gastroenterol. 2015;50:53–65.CrossRefPubMed
2.
Latella G, Rogler G, Bamias G, et al. Results of the 4th scientific workshop of the ECCO (I): pathophysiology of intestinal fibrosis in IBD. J Crohns Colitis. 2014;8:1147–1165.CrossRefPubMed
3.
4.
Swamy SM, Rajasekaran NS, Thannickal VJ. Nuclear factor–erythroid-2–related factor 2 in aging and lung fibrosis. Am J Pathol. 2016;186:1712–1723.CrossRefPubMedPubMedCentral
5.
6.
Ahamed J, Laurence J. Role of platelet-derived transforming growth factor-β1 and reactive oxygen species in radiation-induced organ fibrosis. Antioxid Redox Signal. 2017;27:977–988.CrossRefPubMed
7.
8.
Metadata
Title
Concise Commentary: Is Nrf2 a Master Regulator of Intestinal Fibrosis?
Author
Giovanni Latella
Publication date
01-02-2018
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 2/2018
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-017-4886-2

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