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Open Access 01-06-2011 | Original Paper

Concentrated autologous bone marrow aspirate transplantation treatment for corticosteroid-induced osteonecrosis of the femoral head in systemic lupus erythematosus

Authors: Tomokazu Yoshioka, Hajime Mishima, Hiroshi Akaogi, Shinsuke Sakai, Meihua Li, Naoyuki Ochiai

Published in: International Orthopaedics | Issue 6/2011

Abstract

The purpose of this study was to evaluate concentrated autologous bone marrow aspirate transplantation (CABMAT) treatment for corticosteroid-induced osteonecrosis of the femoral head (ONFH) in systemic lupus erythematosus (SLE). Bone marrow was aspirated from iliac crests, concentrated on a conventional manual blood bag centrifugation technique that is used to extract buffy coats and then injected into nine hips with drilling. The mean number of nucleated cells for transplantation was 5.32 × 10⁷ cells/ml. This cell concentration was significantly higher after concentration, and the mean concentration ratio was 5.5. At follow-up (minimum: three years), significant improvement in pain and Harris Hip Score was observed. For eight of nine hips, we successfully preserved the femoral head. However, one hip required total hip arthroplasty 45 months after the operation. CABMAT using our centrifugation technique is an effective, safe and low-cost procedure of therapeutic osteogenesis for corticosteroid-induced ONFH in SLE.

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Title: Concentrated autologous bone marrow aspirate transplantation treatment for corticosteroid-induced osteonecrosis of the femoral head in systemic lupus erythematosus
Authors: Tomokazu Yoshioka
Hajime Mishima
Hiroshi Akaogi
Shinsuke Sakai
Meihua Li
Naoyuki Ochiai
Publication date: 01-06-2011
Publisher: Springer-Verlag
Published in: International Orthopaedics / Issue 6/2011
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-010-1048-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Concentrated autologous bone marrow aspirate transplantation treatment for corticosteroid-induced osteonecrosis of the femoral head in systemic lupus erythematosus

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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