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Open Access 01-12-2023 | Computed Tomography | Original Article

Role of breath-hold lung PET in stage IA pulmonary adenocarcinoma

Authors: Zhaoping Cheng, Li Chen, Ximing Wang, Ying Wang, Minjie Zhao, Keyu Zan, Wen Liu, Xiao Cui, Leiying Chai, Min Ge, Kun Li, Yanhua Duan

Published in: Insights into Imaging | Issue 1/2023

Abstract

Background

Respiratory motion during PET acquisition may result in image blurring and resolution loss, reduced measurement of radiotracer uptake, and consequently, inaccurate lesion quantification and description. With the introduction of the total-body PET system, short-time PET acquisition is feasible due to its high sensitivity and spatial resolution. The purpose of this study was to evaluate the additional value of 20-s breath-hold (BH) lung PET in patients with stage IA pulmonary adenocarcinoma.

Methods

Forty-seven patients with confirmed stage IA pulmonary adenocarcinoma were enrolled in this retrospective study. All patients underwent a 300-s FB whole-body PET, followed by a BH lung PET. The SUV_max, TBR of the lesions and the percentage difference in nodule SUV_max (%ΔSUV_max) and TBR (%ΔTBR) between the two acquisitions was also calculated. The lesions were further divided by distance from pleura for subgroup analysis. The lesion detectability on PET images was the percentage of FDG-positive lesions.

Results

Among 47 patients, the BH lung PET images identified all lung nodules, and there was a significant difference in overall nodule SUV_max and TBR between BH PET and FB PET (both p < 0.01). The %ΔSUV_max and %ΔTBR were significantly higher in nodules adjacent to pleura (≤ 10 mm in distance) than those away from pleura (both p < 0.05). The lesion detectability of BH lung PET was significantly higher than that of FB PET (p < 0.01).

Conclusion

BH PET acquisition is a practical way to minimize motion artifacts in PET which has the potential to improve lesion detection for stage IA pulmonary adenocarcinoma.

Critical relevance statement

BH PET acquisition is a practical way to minimize motion artifacts in PET which has the potential to improve lesion detection for stage IA pulmonary adenocarcinoma.

Graphical Abstract

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Title: Role of breath-hold lung PET in stage IA pulmonary adenocarcinoma
Authors: Zhaoping Cheng
Li Chen
Ximing Wang
Ying Wang
Minjie Zhao
Keyu Zan
Wen Liu
Xiao Cui
Leiying Chai
Min Ge
Kun Li
Yanhua Duan
Publication date: 01-12-2023
Publisher: Springer Vienna
Keywords: Computed Tomography
Computed Tomography
Pulmonary Nodule
Published in: Insights into Imaging / Issue 1/2023
Electronic ISSN: 1869-4101
DOI: https://doi.org/10.1186/s13244-023-01446-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Role of breath-hold lung PET in stage IA pulmonary adenocarcinoma

Abstract

Background

Methods

Results

Conclusion

Critical relevance statement

Graphical Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Critical relevance statement

Graphical Abstract

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