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Open Access 01-12-2023 | Computed Tomography | Research

Effects of 30% vs. 60% inspired oxygen fraction during mechanical ventilation on postoperative atelectasis: a randomised controlled trial

Authors: Zhaoshun Jiang, Songbin Liu, Lan Wang, Wanling Li, Cheng Li, Feifei Lang, Ruoxi Li, Yue Zhou, Jiajun Wu, Yuxi Cai, Wen Xu, Zhen Chen, Zhijun Bao, Ming Li, Weidong Gu

Published in: BMC Anesthesiology | Issue 1/2023

Abstract

Background

There is the ongoing debate over the effect of inspired oxygen fraction (FiO₂) during mechanical ventilation on postoperative atelectasis. We aimed to compare the effects of low (30%) and moderate (60%) FiO₂ on postoperative atelectasis. The hypothesis of the study was that 30% FiO₂ during mechanical ventilation could reduce postoperative atelectasis volume compared with 60% FiO₂.

Methods

We performed a randomized controlled trial with 120 patients. Subjects were randomly assigned to receive 30% or 60% FiO₂ during mechanical ventilation in a 1:1 ratio. The primary outcome was the percentage of postoperative atelectasis volume in the total lung measured using chest CT within 30 min after extubation. The secondary outcomes included different aeration region volumes, incidence of clinically significant atelectasis, and oxygenation index.

Results

In total, 113 subjects completed the trial, including 55 and 58 subjects in the 30% and 60% FiO₂ groups, respectively. The percentage of the postoperative atelectasis volume in the 30% FiO₂ group did not differ from that in the 60% FiO₂ group. Furthermore, there was no significant difference in the atelectasis volume between the two groups after the missing data were imputed by multiple imputation. Additionally, there were no significant differences in the volumes of the over-aeration, normal-aeration, and poor-aeration regions between the groups. No significant differences in the incidence of clinically significant atelectasis or oxygenation index at the end of surgery were observed between the groups.

Conclusions

Compared with 60% FiO₂, the use of 30% FiO₂ during mechanical ventilation does not reduce the postoperative atelectasis volume.

Trial registration

Chinese Clinical Trial Registry (http://www.chictr.org.cn). Identifier: ChiCTR1900021635. Date: 2 March 2019. Principal invetigator: Weidong Gu.

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Title: Effects of 30% vs. 60% inspired oxygen fraction during mechanical ventilation on postoperative atelectasis: a randomised controlled trial
Authors: Zhaoshun Jiang
Songbin Liu
Lan Wang
Wanling Li
Cheng Li
Feifei Lang
Ruoxi Li
Yue Zhou
Jiajun Wu
Yuxi Cai
Wen Xu
Zhen Chen
Zhijun Bao
Ming Li
Weidong Gu
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Computed Tomography
Computed Tomography
Published in: BMC Anesthesiology / Issue 1/2023
Electronic ISSN: 1471-2253
DOI: https://doi.org/10.1186/s12871-023-02226-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of 30% vs. 60% inspired oxygen fraction during mechanical ventilation on postoperative atelectasis: a randomised controlled trial

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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