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Critical Care
Published in: Critical Care 1/2020

Open Access 01-12-2020 | Computed Tomography | Research Letter

Detection of IgG antibody during the follow-up in patients with COVID-19 infection

Authors: Jiao Liu, Jun Guo, Qianghong Xu, Guolong Cai, Dechang Chen, Yanfei Shen

Published in: Critical Care | Issue 1/2020

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Excerpt

Although most patients with COVID-19 in China have been cured and discharged, we noticed a small proportion of these patients had re-positive RT-PCR test during the follow-up period [1]. The causes of this re-infection remain unclear. In common COVID-19 cases [2], both the IgM and IgG antibodies significantly increased within a short period. However, in a case series report [3], the IgG was relatively low in re-infected COVID-19 cases. Thus, we investigated the IgG status in recovered patients during the follow-up period. …
Literature
1.
Lan L, Xu D, Ye G, Xia C, Wang S, Li Y, Xu H. Positive RT-PCR test results in patients recovered from COVID-19. JAMA. 2020;323(15):1502–3.
2.
Zhang W, Du RH, Li B, Zheng XS, Yang XL, Hu B, Wang YY, Xiao GF, Yan B, Shi ZL, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect. 2020;9(1):386–9.CrossRef
3.
Qin W, Sun G, Zhang Y, et al. Patients with COVID-19 testing positive for nucleic acids of SARS-CoV2 in re-examination after discharge from hospital: an analysis of three cases. Chinese J Virol. 2020;10(2);1–4.
4.
Wang F, Nie J, Wang H, Zhao Q, Xiong Y, Deng L, Song S, Ma Z, Mo P, Zhang Y. Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia. J Infect Dis. 2020;221(11):1762–9.CrossRef
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Azkur AK, Akdis M, Azkur D, Sokolowska M, van de Veen W, Bruggen MC, O'Mahony L, Gao Y, Nadeau K, Akdis CA. Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19. Allergy. 2020;75(7):1564–81.
Metadata
Title
Detection of IgG antibody during the follow-up in patients with COVID-19 infection
Authors
Jiao Liu
Jun Guo
Qianghong Xu
Guolong Cai
Dechang Chen
Yanfei Shen
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03138-4

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