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01-09-2020 | Computed Tomography | Original Article

¹⁸F-FDG uptake as a predictive factor for progressive aortic enlargement in aortic dissection

Authors: Takatoshi Higashigawa, Yasutaka Ichikawa, Shuji Chino, Ken Nakajima, Takafumi Ouchi, Hiroaki Kato, Koji Hirano, Toshiya Tokui, Noriyuki Kato, Hajime Sakuma

Published in: Annals of Nuclear Medicine | Issue 9/2020

Abstract

Objective

Progressive aortic enlargement (PAE) is a critical adverse event in patients with medically treated aortic dissection (AD). However, no reliable predictor of the PAE has been established. The purpose of this study was to evaluate the value of ¹⁸F-FDG PET/CT for the prediction of PAE in patients with medically treated AD.

Methods

Sixteen patients with AD who underwent optimal medical therapy were enrolled. ¹⁸F-FDG PET/CT examinations were performed in subacute phase (2 weeks–3 months) after the onset of AD. Target-to-background ratio (TBR) was measured as the maximum standardized uptake value (SUV) in the dissected aortic wall divided by blood pool SUV. The relation between TBR and occurrence of PAE (> 10 mm/year) was evaluated.

Results

PAE was observed in four patients during the median follow-up period of 24 months. The TBR measured in the 4 patients showing PAE was significantly higher than that in the remaining 12 patients without PAE (2.44 ± 0.56 vs 1.87 ± 0.33, P = 0.025). The area under the receiver operating characteristic curve of TBR for predicting PAE was 0.82. With a threshold of 2.34, the TBR showed the sensitivity, specificity, and positive and negative predictive value of 75%, 92%, 75%, and 92%, respectively, for the prediction of PAE.

Conclusions

Higher ¹⁸F-FDG uptake in the dissected aortic wall as determined by TBR is associated with increased risk of PAE in patients with medically treated AD. TBR shows good specificity and negative predictive value for predicting PAE.

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Title: 18F-FDG uptake as a predictive factor for progressive aortic enlargement in aortic dissection
Authors: Takatoshi Higashigawa
Yasutaka Ichikawa
Shuji Chino
Ken Nakajima
Takafumi Ouchi
Hiroaki Kato
Koji Hirano
Toshiya Tokui
Noriyuki Kato
Hajime Sakuma
Publication date: 01-09-2020
Publisher: Springer Singapore
Keywords: Computed Tomography
Computed Tomography
Positron Emission Tomography
Aortic Dissection
Published in: Annals of Nuclear Medicine / Issue 9/2020
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-020-01487-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

¹⁸F-FDG uptake as a predictive factor for progressive aortic enlargement in aortic dissection

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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