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01-04-2016 | Note

Composition of the endophytic filamentous fungi associated with Cinchona ledgeriana seeds and production of Cinchona alkaloids

Authors: Shoji Maehara, Andria Agusta, Chinami Kitamura, Kazuyoshi Ohashi, Hirotaka Shibuya

Published in: Journal of Natural Medicines | Issue 2/2016

Abstract

Four kinds of endophytic filamentous fungi (code names: CLS-1, CLS-2, CLS-3, and CLS-4) associated with the seeds of Cinchona ledgeriana (Rubiaceae) from West Java, Indonesia, were isolated. All of the isolates were classified into Diaporthe spp. based on phylogenetic analysis of the nucleotide sequences of the internal transcribed spacers (ITS1 and ITS2) including the 5.8S ribosomal DNA region. All four of these endophytic fungi produce Cinchona alkaloids, mainly quinine and quinidine, in synthetic liquid medium.

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Title: Composition of the endophytic filamentous fungi associated with Cinchona ledgeriana seeds and production of Cinchona alkaloids
Authors: Shoji Maehara
Andria Agusta
Chinami Kitamura
Kazuyoshi Ohashi
Hirotaka Shibuya
Publication date: 01-04-2016
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 2/2016
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-015-0954-0

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Composition of the endophytic filamentous fungi associated with Cinchona ledgeriana seeds and production of Cinchona alkaloids

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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