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Journal of Natural Medicines
Published in: Journal of Natural Medicines 2/2013

01-04-2013 | Note

Ability of endophytic filamentous fungi associated with Cinchona ledgeriana to produce Cinchona alkaloids

Authors: Shoji Maehara, Partomuan Simanjuntak, Yoshihide Maetani, Chinami Kitamura, Kazuyoshi Ohashi, Hirotaka Shibuya

Published in: Journal of Natural Medicines | Issue 2/2013

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Abstract

We have investigated the ability of endophytic filamentous fungi associated with Cinchona ledgeriana (Rubiaceae) to produce Cinchona alkaloids on potato dextrose agar medium and in a synthetic liquid medium. It was found that all twenty-one endophytic fungi produce Cinchona alkaloids, despite their genetic differences.
Literature
1.
Shibuya H, Kitamura C, Maehara S, Nagahata M, Winarno H, Simanjuntak P, Kim H-S, Wataya Y, Ohashi K (2003) Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens. Chem Pharm Bull 51:71–74PubMedCrossRef
2.
Shibuya H, Agusta A, Ohashi K, Maehara S, Simanjuntak P (2005) Biooxidation of (+)-catechin and (–)-epicatechin into 3,4-dihydroxyflavan derivatives by the endophytic fungus Diaporthe sp. isolated from a tea plant. Chem Pharm Bull 53:866–867PubMedCrossRef
3.
Agusta A, Maehara S, Ohashi K, Simanjuntak P, Shibuya H (2005) Stereoselective oxidation at C-4 of flavans by the endophytic fungus Diaporthe sp. isolated from a tea plant. Chem Pharm Bull 53:1565–1569PubMedCrossRef
4.
Agusta A, Ohashi K, Shibuya H (2006) Composition of the endophytic filamentous fungi isolated from the tea plant Camellia sinensis. J Nat Med 60:268–272CrossRef
5.
Maehara S, Simanjuntak P, Ohashi K, Shibuya H (2010) Composition of endophytic fungi living in Cinchona ledgeriana (Rubiaceae). J Nat Med 64:227–230PubMedCrossRef
6.
Maehara S, Simanjuntak P, Kitamura C, Ohashi K, Shibuya H (2011) Cinchona alkaloids are also produced by an endophytic filamentous fungus living in Cinchona plant. Chem Pharm Bull 59:1073–1074PubMedCrossRef
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Trimen H (1881) Cinchona ledgeriana a distinct species. J Bot Br Foreign 19:321–325
Metadata
Title
Ability of endophytic filamentous fungi associated with Cinchona ledgeriana to produce Cinchona alkaloids
Authors
Shoji Maehara
Partomuan Simanjuntak
Yoshihide Maetani
Chinami Kitamura
Kazuyoshi Ohashi
Hirotaka Shibuya
Publication date
01-04-2013
Publisher
Springer Japan
Published in
Journal of Natural Medicines / Issue 2/2013
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-012-0701-8

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