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International Journal of Hematology
Published in: International Journal of Hematology 1/2017

01-07-2017 | Progress in Hematology

Complexity of bone marrow hematopoietic stem cell niche

Authors: Noboru Asada, Shoichiro Takeishi, Paul S. Frenette

Published in: International Journal of Hematology | Issue 1/2017

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Abstract

Hematopoietic stem cells (HSCs) that produce a variety of hematopoietic lineage cells throughout the life reside in specialized microenvironment called “niche” in the bone marrow (BM) where they are tightly regulated. With the recent advances in experimental technologies enabling the selective deletion of molecules, various types of cells in the BM have been proposed to contribute to HSC niche activity. Among these are stromal cells closely associated with the vasculature. In this review, we provide an overview of recent advances in HSC niche research, and focus on the studies describing the functional roles of perivascular cells for HSC maintenance and mobilization. Not only for physiologic state, we also discuss the recent evidences suggesting the importance of microenvironment for emergence of malignant hematopoietic diseases.
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Metadata
Title
Complexity of bone marrow hematopoietic stem cell niche
Authors
Noboru Asada
Shoichiro Takeishi
Paul S. Frenette
Publication date
01-07-2017
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 1/2017
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-017-2262-9

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